DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LTPPPT
Uniprot ID:
P13637
Source protein:
Sodium/potassium-transporting ATPase subunit alpha-3
Source gene:
ATP1A3
Class:
DEG_SCF_FBW7_1
Location:
70:75
E3 ligase:
FBXW7
DEGRON score:
0.8645
ASA_SCORE:
84.1167
COIL:
0.9337
CONS_SCORE:
0.4949
DSS_SCORE:
0.4295
HELIX:
0.01
FCONS_SCORE:
1.1011
RIG_SCORE:
0.6961
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T84M
TCGA-AK-3465
KIRC
TCGA
LTPPPT
DEG_SCF_FBW7_1
0.0833
p.T84M
DO222412
BTCA
ICGC
LTPPPT
DEG_SCF_FBW7_1
0.0833
p.P80L
TCGA-B9-7268
KIRP
TCGA
LTPPPT
DEG_SCF_FBW7_1
0.1944
p.P80L
DO20817
KIRP
ICGC
LTPPPT
DEG_SCF_FBW7_1
0.1944
p.A76D
TCGA-CC-A7II
LIHC
TCGA
LTPPPT
DEG_SCF_FBW7_1
0.3056
p.A76D
DO52182
LIHC
ICGC
LTPPPT
DEG_SCF_FBW7_1
0.3056
p.A82T
TCGA-EB-A85I
SKCM
TCGA
LTPPPT
DEG_SCF_FBW7_1
0.1389
p.A82T
TCGA-LH-A9QB
SKCM
TCGA
LTPPPT
DEG_SCF_FBW7_1
0.1389
p.A82T
DO228138
PBCA
ICGC
LTPPPT
DEG_SCF_FBW7_1
0.1389
p.A82T
DO50296
SKCM
ICGC
LTPPPT
DEG_SCF_FBW7_1
0.1389
p.A82T
DO51266
SKCM
ICGC
LTPPPT
DEG_SCF_FBW7_1
0.1389
p.K70E
TCGA-EJ-5495
PRAD
TCGA
LTPPPT
DEG_SCF_FBW7_1
0.7022
p.K70E
DO36258
PRAD
ICGC
LTPPPT
DEG_SCF_FBW7_1
0.7022
p.D61G
TCGA-EP-A26S
LIHC
TCGA
LTPPPT
DEG_SCF_FBW7_1
0.0833
p.D61G
DO22854
LIHC
ICGC
LTPPPT
DEG_SCF_FBW7_1
0.0833
p.R77W
TCGA-FR-A729
SKCM
TCGA
LTPPPT
DEG_SCF_FBW7_1
0.2778
p.R77W
DO48618
SKCM
ICGC
LTPPPT
DEG_SCF_FBW7_1
0.2778
p.L83I
DO229018
LICA
ICGC
LTPPPT
DEG_SCF_FBW7_1
0.1111
p.D61E
DO232224
PBCA
ICGC
LTPPPT
DEG_SCF_FBW7_1
0.0833
p.G79R
SIDM00527
Colorectal Carcinoma
GDSC
LTPPPT
DEG_SCF_FBW7_1
0.2222
p.G79R
MDST8
large_intestine
COSMIC
LTPPPT
DEG_SCF_FBW7_1
0.2222
p.K81M
ACH-000030
Lung Cancer
CCLE
LTPPPT
DEG_SCF_FBW7_1
0.2778
p.K81M
PC-14
lung
COSMIC
LTPPPT
DEG_SCF_FBW7_1
0.2778
p.G66R
ACH-000935
Colon/Colorectal Cancer
CCLE
LTPPPT
DEG_SCF_FBW7_1
0.2222
p.G66R
MDST8
large_intestine
COSMIC
LTPPPT
DEG_SCF_FBW7_1
0.2222
p.C83Y
ACH-002256
Leukemia
CCLE
LTPPPT
DEG_SCF_FBW7_1
0.1111
p.C83Y
KARPAS-45
haematopoietic_and_lymphoid_tissue
COSMIC
LTPPPT
DEG_SCF_FBW7_1
0.1111
p.Y75C
HT
haematopoietic_and_lymphoid_tissue
COSMIC
LTPPPT
DEG_SCF_FBW7_1
0.7087
p.G77R
MDST8
large_intestine
COSMIC
LTPPPT
DEG_SCF_FBW7_1
0.2778
Drug responses associated with ATP1A3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LTPPPT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P05023
Sodium/potassium-transporting ATPase subunit alpha-1
DEG_SCF_FBW7_1
80:85
LTPPPT
FBXW7
0.9411
More...
P13637
Sodium/potassium-transporting ATPase subunit alpha-3
DEG_SCF_FBW7_1
70:75
LTPPPT
FBXW7
0.8645
More...
P50993
Sodium/potassium-transporting ATPase subunit alpha-2
DEG_SCF_FBW7_1
78:83
LTPPPT
FBXW7
0.8847
More...