DegronMD

Uniprot ID: P13637

Source protein: Sodium/potassium-transporting ATPase subunit alpha-3

Source gene: ATP1A3

Class: DEG_SCF_FBW7_1

Location: 70:75

E3 ligase: FBXW7

DEGRON score: 0.8645

ASA_SCORE: 84.1167

COIL: 0.9337

CONS_SCORE: 0.4949

DSS_SCORE: 0.4295

HELIX: 0.01

FCONS_SCORE: 1.1011

RIG_SCORE: 0.6961

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y75C	HT	haematopoietic_and_lymphoid_tissue	COSMIC	LTPPPT	DEG_SCF_FBW7_1	0.7087
p.K70E	TCGA-EJ-5495	PRAD	TCGA	LTPPPT	DEG_SCF_FBW7_1	0.7022
p.K70E	DO36258	PRAD	ICGC	LTPPPT	DEG_SCF_FBW7_1	0.7022
p.A76D	TCGA-CC-A7II	LIHC	TCGA	LTPPPT	DEG_SCF_FBW7_1	0.3056
p.A76D	DO52182	LIHC	ICGC	LTPPPT	DEG_SCF_FBW7_1	0.3056
p.R77W	TCGA-FR-A729	SKCM	TCGA	LTPPPT	DEG_SCF_FBW7_1	0.2778
p.R77W	DO48618	SKCM	ICGC	LTPPPT	DEG_SCF_FBW7_1	0.2778
p.K81M	ACH-000030	Lung Cancer	CCLE	LTPPPT	DEG_SCF_FBW7_1	0.2778
p.K81M	PC-14	lung	COSMIC	LTPPPT	DEG_SCF_FBW7_1	0.2778
p.G77R	MDST8	large_intestine	COSMIC	LTPPPT	DEG_SCF_FBW7_1	0.2778
p.G79R	SIDM00527	Colorectal Carcinoma	GDSC	LTPPPT	DEG_SCF_FBW7_1	0.2222
p.G79R	MDST8	large_intestine	COSMIC	LTPPPT	DEG_SCF_FBW7_1	0.2222
p.G66R	ACH-000935	Colon/Colorectal Cancer	CCLE	LTPPPT	DEG_SCF_FBW7_1	0.2222
p.G66R	MDST8	large_intestine	COSMIC	LTPPPT	DEG_SCF_FBW7_1	0.2222
p.P80L	TCGA-B9-7268	KIRP	TCGA	LTPPPT	DEG_SCF_FBW7_1	0.1944
p.P80L	DO20817	KIRP	ICGC	LTPPPT	DEG_SCF_FBW7_1	0.1944
p.A82T	TCGA-EB-A85I	SKCM	TCGA	LTPPPT	DEG_SCF_FBW7_1	0.1389
p.A82T	TCGA-LH-A9QB	SKCM	TCGA	LTPPPT	DEG_SCF_FBW7_1	0.1389
p.A82T	DO228138	PBCA	ICGC	LTPPPT	DEG_SCF_FBW7_1	0.1389
p.A82T	DO50296	SKCM	ICGC	LTPPPT	DEG_SCF_FBW7_1	0.1389
p.A82T	DO51266	SKCM	ICGC	LTPPPT	DEG_SCF_FBW7_1	0.1389
p.L83I	DO229018	LICA	ICGC	LTPPPT	DEG_SCF_FBW7_1	0.1111
p.C83Y	ACH-002256	Leukemia	CCLE	LTPPPT	DEG_SCF_FBW7_1	0.1111
p.C83Y	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LTPPPT	DEG_SCF_FBW7_1	0.1111
p.T84M	TCGA-AK-3465	KIRC	TCGA	LTPPPT	DEG_SCF_FBW7_1	0.0833

Showing 1 to 25 of 29 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05023	Sodium/potassium-transporting ATPase subunit alpha-1	DEG_SCF_FBW7_1	80:85	LTPPPT	FBXW7	0.9411	More...
P50993	Sodium/potassium-transporting ATPase subunit alpha-2	DEG_SCF_FBW7_1	78:83	LTPPPT	FBXW7	0.8847	More...
P13637	Sodium/potassium-transporting ATPase subunit alpha-3	DEG_SCF_FBW7_1	70:75	LTPPPT	FBXW7	0.8645	More...

Showing 1 to 3 of 3 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons