DegronMD

Uniprot ID: P50993

Source protein: Sodium/potassium-transporting ATPase subunit alpha-2

Source gene: ATP1A2

Class: DEG_SCF_FBW7_1

Location: 78:83

E3 ligase: FBXW7

DEGRON score: 0.8847

ASA_SCORE: 83.6667

COIL: 0.9165

CONS_SCORE: 0.522

DSS_SCORE: 0.4485

HELIX: 0.0102

FCONS_SCORE: 1.1224

RIG_SCORE: 0.6907

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A71S	TCGA-33-4586	LUSC	TCGA	LTPPPT	DEG_SCF_FBW7_1	0.1389
p.A71S	DO229018	LICA	ICGC	LTPPPT	DEG_SCF_FBW7_1	0.1389
p.A71S	DO27318	LUSC	ICGC	LTPPPT	DEG_SCF_FBW7_1	0.1389
p.R92H	TCGA-AB-2935	LAML	TCGA	LTPPPT	DEG_SCF_FBW7_1	0.0833
p.R92H	DO50443	ESAD	ICGC	LTPPPT	DEG_SCF_FBW7_1	0.0833
p.R92H	DO21176	LAML	ICGC	LTPPPT	DEG_SCF_FBW7_1	0.0833
p.R92H	SIDM01092	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPPPT	DEG_SCF_FBW7_1	0.0833
p.R92H	RF-48	stomach	COSMIC	LTPPPT	DEG_SCF_FBW7_1	0.0833
p.G74R	TCGA-B8-4620	KIRC	TCGA	LTPPPT	DEG_SCF_FBW7_1	0.2222
p.G74R	DO19893	KIRC	ICGC	LTPPPT	DEG_SCF_FBW7_1	0.2222
p.R72L	TCGA-B9-4115	KIRP	TCGA	LTPPPT	DEG_SCF_FBW7_1	0.1667
p.R72L	DO20768	KIRP	ICGC	LTPPPT	DEG_SCF_FBW7_1	0.1667
p.T84A	TCGA-BH-A18G	BRCA	TCGA	LTPPPT	DEG_SCF_FBW7_1	0.3056
p.T84A	DO3686	BRCA	ICGC	LTPPPT	DEG_SCF_FBW7_1	0.3056
p.R72Q	TCGA-BS-A0UV	UCEC	TCGA	LTPPPT	DEG_SCF_FBW7_1	0.1667
p.R72Q	DO42793	UCEC	ICGC	LTPPPT	DEG_SCF_FBW7_1	0.1667
p.R72Q	ACH-001538	Bile Duct Cancer	CCLE	LTPPPT	DEG_SCF_FBW7_1	0.1667
p.E86K	TCGA-EE-A3JB	SKCM	TCGA	LTPPPT	DEG_SCF_FBW7_1	0.25
p.E86K	DO51250	SKCM	ICGC	LTPPPT	DEG_SCF_FBW7_1	0.25
p.A77V	TCGA-F7-A624	HNSC	TCGA	LTPPPT	DEG_SCF_FBW7_1	0.3056
p.A77V	DO44440	HNSC	ICGC	LTPPPT	DEG_SCF_FBW7_1	0.3056
p.K89T	TCGA-L5-A893	ESCA	TCGA	LTPPPT	DEG_SCF_FBW7_1	0.2778
p.N76K	TCGA-XF-AAMX	BLCA	TCGA	LTPPPT	DEG_SCF_FBW7_1	0.2778
p.N76K	DO51939	BLCA	ICGC	LTPPPT	DEG_SCF_FBW7_1	0.2778
p.T83R	SIDM01117	Small Cell Lung Carcinoma	GDSC	LTPPPT	DEG_SCF_FBW7_1	0.7876
p.T83R	ACH-002176	Lung Cancer	CCLE	LTPPPT	DEG_SCF_FBW7_1	0.7876
p.T83R	NCI-H748	lung	COSMIC	LTPPPT	DEG_SCF_FBW7_1	0.7876
p.R72P	SIDM00842	Colorectal Carcinoma	GDSC	LTPPPT	DEG_SCF_FBW7_1	0.1667
p.V69I	SIDM00136	Colorectal Carcinoma	GDSC	LTPPPT	DEG_SCF_FBW7_1	0.0833
p.V69I	ACH-000552	Colon/Colorectal Cancer	CCLE	LTPPPT	DEG_SCF_FBW7_1	0.0833
p.V69I	HT-29	large_intestine	COSMIC	LTPPPT	DEG_SCF_FBW7_1	0.0833
p.A77T	SIDM00217	Colorectal Carcinoma	GDSC	LTPPPT	DEG_SCF_FBW7_1	0.3056
p.A77T	ACH-000999	Colon/Colorectal Cancer	CCLE	LTPPPT	DEG_SCF_FBW7_1	0.3056
p.A77T	SNU-1040	large_intestine	COSMIC	LTPPPT	DEG_SCF_FBW7_1	0.3056
p.P85H	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPPPT	DEG_SCF_FBW7_1	0.2778
p.P85H	ACH-001498	Lymphoma	CCLE	LTPPPT	DEG_SCF_FBW7_1	0.2778
p.P85H	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	LTPPPT	DEG_SCF_FBW7_1	0.2778
p.C91R	ACH-000800	Lung Cancer	CCLE	LTPPPT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05023	Sodium/potassium-transporting ATPase subunit alpha-1	DEG_SCF_FBW7_1	80:85	LTPPPT	FBXW7	0.9411	More...
P13637	Sodium/potassium-transporting ATPase subunit alpha-3	DEG_SCF_FBW7_1	70:75	LTPPPT	FBXW7	0.8645	More...
P50993	Sodium/potassium-transporting ATPase subunit alpha-2	DEG_SCF_FBW7_1	78:83	LTPPPT	FBXW7	0.8847	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPPPT

Degron related mutations and impact score

Drug responses associated with ATP1A2 mutations

All proteins holding degron of LTPPPT