DegronMD - P50993(ATP1A2)

FUNCTION: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.

GO - Biological processes (BP): adult locomotory behavior [GO:0008344]; amygdala development [GO:0021764]; ATP metabolic process [GO:0046034]; behavioral fear response [GO:0001662]; cardiac muscle contraction [GO:0060048]; cation transmembrane transport [GO:0098655]; cell communication by electrical coupling involved in cardiac co... adult locomotory behavior [GO:0008344]; amygdala development [GO:0021764]; ATP metabolic process [GO:0046034]; behavioral fear response [GO:0001662]; cardiac muscle contraction [GO:0060048]; cation transmembrane transport [GO:0098655]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular potassium ion homeostasis [GO:0030007]; cellular response to mechanical stimulus [GO:0071260]; cellular response to steroid hormone stimulus [GO:0071383]; cellular sodium ion homeostasis [GO:0006883]; locomotion [GO:0040011]; locomotory exploration behavior [GO:0035641]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; membrane repolarization [GO:0086009]; negative regulation of calcium:sodium antiporter activity [GO:1903280]; negative regulation of calcium ion transmembrane transport [GO:1903170]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of heart contraction [GO:0045822]; negative regulation of striated muscle contraction [GO:0045988]; neurotransmitter uptake [GO:0001504]; olfactory cortex development [GO:0021989]; positive regulation of heart contraction [GO:0045823]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; proton transmembrane transport [GO:1902600]; regulation of blood pressure [GO:0008217]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of glutamate uptake involved in transmission of nerve impulse [GO:0051946]; regulation of muscle contraction [GO:0006937]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of smooth muscle contraction [GO:0006940]; regulation of striated muscle contraction [GO:0006942]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of the force of heart contraction [GO:0002026]; regulation of vasoconstriction [GO:0019229]; relaxation of cardiac muscle [GO:0055119]; response to auditory stimulus [GO:0010996]; response to glycoside [GO:1903416]; response to nicotine [GO:0035094]; sodium ion export across plasma membrane [GO:0036376]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; transport across blood-brain barrier [GO:0150104]; visual learning [GO:0008542] View more >>

GO - Molecular function (MF): ATPase-coupled cation transmembrane transporter activity [GO:0019829]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chaperone binding [GO:0051087]; phosphatase activity [GO:0016791]; potassium ion binding [GO:0030955]; protein heterodimerization activity [GO:0046982]; P-type sodiu... View more >>

GO - Cellular component (CC): caveola [GO:0005901]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; endosome [GO:0005768]; extracellular vesicle [GO:1903561]; intercalated disc [GO:0014704]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; organelle membrane [GO:0031090]; plasma membran... View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T83R	SIDM01117	Small Cell Lung Carcinoma	GDSC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation altering degron motif	0.7876
p.T83R	ACH-002176	Lung Cancer	CCLE	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation altering degron motif	0.7876
p.T83R	NCI-H748	lung	COSMIC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation altering degron motif	0.7876
p.T84A	TCGA-BH-A18G	BRCA	TCGA	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.3056
p.T84A	DO3686	BRCA	ICGC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.3056
p.A77V	TCGA-F7-A624	HNSC	TCGA	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.3056
p.A77V	DO44440	HNSC	ICGC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.3056
p.A77T	SIDM00217	Colorectal Carcinoma	GDSC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.3056
p.A77T	ACH-000999	Colon/Colorectal Cancer	CCLE	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.3056
p.A77T	SNU-1040	large intestine	COSMIC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.3056
p.K89T	TCGA-L5-A893	ESCA	TCGA	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation substituting flanking lysine	0.2778
p.N76K	TCGA-XF-AAMX	BLCA	TCGA	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.2778
p.N76K	DO51939	BLCA	ICGC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.2778
p.P85H	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.2778
p.P85H	ACH-001498	Lymphoma	CCLE	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.2778
p.P85H	Farage	haematopoietic and lymphoid tissue	COSMIC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.2778
p.E86K	TCGA-EE-A3JB	SKCM	TCGA	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.25
p.E86K	DO51250	SKCM	ICGC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.25
p.G74R	TCGA-B8-4620	KIRC	TCGA	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.2222
p.G74R	DO19893	KIRC	ICGC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.2222

Showing 1 to 20 of 38 entries

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Kaplan plot for ATP1A2 in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATP1A2

UniProt ID: P50993

Entrez ID: 477

Protein name: Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATP1A2 in