DegronMD - P50993(ATP1A2)

GO - Biological processes (BP): adult locomotory behavior [GO:0008344]; amygdala development [GO:0021764]; ATP metabolic process [GO:0046034]; behavioral fear response [GO:0001662]; cardiac muscle contraction [GO:0060048]; cation transmembrane transport [GO:0098655]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular potassium ion homeostasis [GO:0030007]; cellular response to mechanical stimulus [GO:0071260]; cellular response to steroid hormone stimulus [GO:0071383]; cellular sodium ion homeostasis [GO:0006883]; locomotion [GO:0040011]; locomotory exploration behavior [GO:0035641]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; membrane repolarization [GO:0086009]; negative regulation of calcium:sodium antiporter activity [GO:1903280]; negative regulation of calcium ion transmembrane transport [GO:1903170]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of heart contraction [GO:0045822]; negative regulation of striated muscle contraction [GO:0045988]; neurotransmitter uptake [GO:0001504]; olfactory cortex development [GO:0021989]; positive regulation of heart contraction [GO:0045823]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; proton transmembrane transport [GO:1902600]; regulation of blood pressure [GO:0008217]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of glutamate uptake involved in transmission of nerve impulse [GO:0051946]; regulation of muscle contraction [GO:0006937]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of smooth muscle contraction [GO:0006940]; regulation of striated muscle contraction [GO:0006942]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of the force of heart contraction [GO:0002026]; regulation of vasoconstriction [GO:0019229]; relaxation of cardiac muscle [GO:0055119]; response to auditory stimulus [GO:0010996]; response to glycoside [GO:1903416]; response to nicotine [GO:0035094]; sodium ion export across plasma membrane [GO:0036376]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; transport across blood-brain barrier [GO:0150104]; visual learning [GO:0008542] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A71S	TCGA-33-4586	LUSC	TCGA	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.1389
p.A71S	DO229018	LICA	ICGC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.1389
p.A71S	DO27318	LUSC	ICGC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.1389
p.R92H	TCGA-AB-2935	LAML	TCGA	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.0833
p.R92H	DO50443	ESAD	ICGC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.0833
p.R92H	DO21176	LAML	ICGC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.0833
p.R92H	SIDM01092	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.0833
p.R92H	RF-48	stomach	COSMIC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.0833
p.G74R	TCGA-B8-4620	KIRC	TCGA	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.2222
p.G74R	DO19893	KIRC	ICGC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.2222
p.R72L	TCGA-B9-4115	KIRP	TCGA	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.1667
p.R72L	DO20768	KIRP	ICGC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.1667
p.T84A	TCGA-BH-A18G	BRCA	TCGA	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.3056
p.T84A	DO3686	BRCA	ICGC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.3056
p.R72Q	TCGA-BS-A0UV	UCEC	TCGA	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.1667
p.R72Q	DO42793	UCEC	ICGC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.1667
p.R72Q	ACH-001538	Bile Duct Cancer	CCLE	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.1667
p.E86K	TCGA-EE-A3JB	SKCM	TCGA	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.25
p.E86K	DO51250	SKCM	ICGC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.25
p.A77V	TCGA-F7-A624	HNSC	TCGA	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.3056
p.A77V	DO44440	HNSC	ICGC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.3056
p.K89T	TCGA-L5-A893	ESCA	TCGA	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation substituting flanking lysine	0.2778
p.N76K	TCGA-XF-AAMX	BLCA	TCGA	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.2778
p.N76K	DO51939	BLCA	ICGC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.2778
p.T83R	SIDM01117	Small Cell Lung Carcinoma	GDSC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation altering degron motif	0.7876
p.T83R	ACH-002176	Lung Cancer	CCLE	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation altering degron motif	0.7876
p.T83R	NCI-H748	lung	COSMIC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation altering degron motif	0.7876
p.R72P	SIDM00842	Colorectal Carcinoma	GDSC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.1667
p.V69I	SIDM00136	Colorectal Carcinoma	GDSC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.0833
p.V69I	ACH-000552	Colon/Colorectal Cancer	CCLE	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.0833
p.V69I	HT-29	large intestine	COSMIC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.0833
p.A77T	SIDM00217	Colorectal Carcinoma	GDSC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.3056
p.A77T	ACH-000999	Colon/Colorectal Cancer	CCLE	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.3056
p.A77T	SNU-1040	large intestine	COSMIC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.3056
p.P85H	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.2778
p.P85H	ACH-001498	Lymphoma	CCLE	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.2778
p.P85H	Farage	haematopoietic and lymphoid tissue	COSMIC	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.2778
p.C91R	ACH-000800	Lung Cancer	CCLE	LTPPPT	DEG_SCF_FBW7_1	78:83	Mutation rewiring degron network	0.1111

Kaplan plot for ATP1A2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATP1A2

UniProt ID: P50993

Entrez ID: 477

Protein name: Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATP1A2 in