ARG1
UniProt ID: P05089
Entrez ID: 383
Protein name: Arginase-1 (EC 3.5.3.1) (Liver-type arginase) (Type I arginase)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in t...
FUNCTION: Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. {ECO:0000305}.; FUNCTION: Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion (PubMed:15546957, PubMed:16709924, PubMed:19380772). In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival (By similarity). In humans, the immunological role in the monocytic/macrophage/dendritic cell (DC) lineage is unsure. {ECO:0000250|UniProtKB:Q61176, ECO:0000269|PubMed:15546957, ECO:0000269|PubMed:16709924, ECO:0000269|PubMed:19380772}.
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GO - Biological processes (BP):
adaptive immune response [GO:0002250]; aging [GO:0007568]; arginine catabolic process [GO:0006527]; arginine catabolic process to ornithine [GO:0019547]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to glucagon stimulus [GO:0071377]; cellular response to hydrogen perox...
adaptive immune response [GO:0002250]; aging [GO:0007568]; arginine catabolic process [GO:0006527]; arginine catabolic process to ornithine [GO:0019547]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to glucagon stimulus [GO:0071377]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to transforming growth factor beta stimulus [GO:0071560]; collagen biosynthetic process [GO:0032964]; defense response to protozoan [GO:0042832]; innate immune response [GO:0045087]; liver development [GO:0001889]; lung development [GO:0030324]; mammary gland involution [GO:0060056]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of interferon-gamma-mediated signaling pathway [GO:0060336]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of T-helper 2 cell cytokine production [GO:2000552]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of neutrophil mediated killing of fungus [GO:0070965]; regulation of L-arginine import across plasma membrane [GO:1905541]; response to amine [GO:0014075]; response to amino acid [GO:0043200]; response to axon injury [GO:0048678]; response to cadmium ion [GO:0046686]; response to herbicide [GO:0009635]; response to manganese ion [GO:0010042]; response to methylmercury [GO:0051597]; response to selenium ion [GO:0010269]; response to vitamin A [GO:0033189]; response to vitamin E [GO:0033197]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; urea cycle [GO:0000050]
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GO - Molecular function (MF):
arginase activity [GO:0004053]; identical protein binding [GO:0042802]; manganese ion binding [GO:0030145]...
arginase activity [GO:0004053]; identical protein binding [GO:0042802]; manganese ion binding [GO:0030145]
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GO - Cellular component (CC):
azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitochondrial outer membrane [GO:0005741]; neuronal cell body [GO:0043025]; neuron projection [GO:0043005]; nucleus [GO:0005634]; specific granule ...
azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitochondrial outer membrane [GO:0005741]; neuronal cell body [GO:0043025]; neuron projection [GO:0043005]; nucleus [GO:0005634]; specific granule lumen [GO:0035580]
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ARG1
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*NOTE: the Kaplan plots were collected from OncoLnc