DegronMD

Uniprot ID: P05089

Source protein: Arginase-1

Source gene: ARG1

Class: DEG_SCF_FBW7_1

Location: 165:170

E3 ligase: FBXW7

DEGRON score: 0.6706

ASA_SCORE: 35.8833

COIL: 0.737

CONS_SCORE: 0.413

DSS_SCORE: 0.0494

HELIX: 0.037

FCONS_SCORE: 0.8217

RIG_SCORE: 0.91

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F170L	TCGA-A2-A0SY	BRCA	TCGA	VTPCIS	DEG_SCF_FBW7_1	0.6981
p.F170L	DO2961	BRCA	ICGC	VTPCIS	DEG_SCF_FBW7_1	0.6981
p.T174I	TCGA-BR-4361	STAD	TCGA	VTPCIS	DEG_SCF_FBW7_1	0.2222
p.T174I	DO38887	STAD	ICGC	VTPCIS	DEG_SCF_FBW7_1	0.2222
p.E159K	TCGA-EB-A3Y7	SKCM	TCGA	VTPCIS	DEG_SCF_FBW7_1	0.1667
p.E159K	DO37499	SKCM	ICGC	VTPCIS	DEG_SCF_FBW7_1	0.1667
p.G162E	TCGA-EB-A85J	SKCM	TCGA	VTPCIS	DEG_SCF_FBW7_1	0.25
p.G162E	DO50297	SKCM	ICGC	VTPCIS	DEG_SCF_FBW7_1	0.25
p.K158N	TCGA-EY-A215	UCEC	TCGA	VTPCIS	DEG_SCF_FBW7_1	0.1389
p.K158N	DO42665	UCEC	ICGC	VTPCIS	DEG_SCF_FBW7_1	0.1389
p.L160I	DO222884	COCA	ICGC	VTPCIS	DEG_SCF_FBW7_1	0.1944
p.C176F	DO229029	LICA	ICGC	VTPCIS	DEG_SCF_FBW7_1	0.1667
p.V167M	DO48911	PBCA	ICGC	VTPCIS	DEG_SCF_FBW7_1	0.7208
p.G162R	SIDM00007	Other Solid Cancers	GDSC	VTPCIS	DEG_SCF_FBW7_1	0.25
p.G162R	MCC13	skin	COSMIC	VTPCIS	DEG_SCF_FBW7_1	0.25
p.I177M	SIDM01018	Hodgkin's Lymphoma	GDSC	VTPCIS	DEG_SCF_FBW7_1	0.1389
p.I177M	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	VTPCIS	DEG_SCF_FBW7_1	0.1389
p.I169M	ACH-000815	Lymphoma	CCLE	VTPCIS	DEG_SCF_FBW7_1	0.6507
p.I169M	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	VTPCIS	DEG_SCF_FBW7_1	0.6507

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05089	Arginase-1	DEG_SCF_FBW7_1	165:170	VTPCIS	FBXW7	0.6706	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons