DegronMD - P05154(SERPINA5)

FUNCTION: Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and pro-inflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue- and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid. {ECO:0000269|PubMed:10340997, ECO:0000269|PubMed:11722589, ECO:0000269|PubMed:14696115, ECO:0000269|PubMed:15140131, ECO:0000269|PubMed:15328353, ECO:0000269|PubMed:15853774, ECO:0000269|PubMed:1725227, ECO:0000269|PubMed:18467335, ECO:0000269|PubMed:2844223, ECO:0000269|PubMed:3501295, ECO:0000269|PubMed:6323392, ECO:0000269|PubMed:7521127, ECO:0000269|PubMed:7548057, ECO:0000269|PubMed:8536714, ECO:0000269|PubMed:8665956, ECO:0000269|PubMed:9473218, ECO:0000269|PubMed:9510955, ECO:0000269|PubMed:9556620}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N395K	TCGA-05-4427	LUAD	TCGA	NRPFLMFIV	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.2778
p.N395K	DO23666	LUAD	ICGC	NRPFLMFIV	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.2778
p.R376S	TCGA-17-Z018	LUAD	TCGA	NRPFLMFIV	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.0833
p.V383M	TCGA-24-1562	OV	TCGA	NRPFLMFIV	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.2778
p.V383M	DO28412	OV	ICGC	NRPFLMFIV	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.2778
p.L398I	TCGA-AX-A2HD	UCEC	TCGA	NRPFLMFIV	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.1944
p.L398I	DO42608	UCEC	ICGC	NRPFLMFIV	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.1944
p.R386M	TCGA-CR-7402	HNSC	TCGA	NRPFLMFIV	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.8632
p.R386M	DO15727	HNSC	ICGC	NRPFLMFIV	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.8632
p.N385H	TCGA-CV-A45W	HNSC	TCGA	NRPFLMFIV	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.6312
p.N385H	DO52060	HNSC	ICGC	NRPFLMFIV	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.6312
p.L400F	TCGA-EE-A2MS	SKCM	TCGA	NRPFLMFIV	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.1389
p.L400F	DO37567	SKCM	ICGC	NRPFLMFIV	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.1389
p.A375S	DO229029	LICA	ICGC	NRPFLMFIV	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.0556
p.L382R	SIDM01611	Endometrial Carcinoma	GDSC	NRPFLMFIV	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.25
p.L382R	ACH-000996	Endometrial/Uterine Cancer	CCLE	NRPFLMFIV	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.25
p.R376H	ACH-000261	Lung Cancer	CCLE	NRPFLMFIV	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.0833
p.R376H	ACH-002122	Lung Cancer	CCLE	NRPFLMFIV	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.0833

Kaplan plot for SERPINA5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SERPINA5

UniProt ID: P05154

Entrez ID: 5104

Protein name: Plasma serine protease inhibitor (Acrosomal serine protease inhibitor) (Plasminogen activator inhibitor 3) (PAI-3) (PAI3) (Protein C inhibitor) (PCI) (Serpin A5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SERPINA5 in