DegronMD

Uniprot ID: P05154

Source protein: Plasma serine protease inhibitor

Source gene: SERPINA5

Class: DEG_APCC_DBOX_1

Location: 385:393

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6529

ASA_SCORE: 23.7889

COIL: 0.323

CONS_SCORE: 0.5911

DSS_SCORE: 0.0096

HELIX: 0.0022

FCONS_SCORE: 1.3572

RIG_SCORE: 0.9631

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N395K	TCGA-05-4427	LUAD	TCGA	NRPFLMFIV	DEG_APCC_DBOX_1	0.2778
p.N395K	DO23666	LUAD	ICGC	NRPFLMFIV	DEG_APCC_DBOX_1	0.2778
p.R376S	TCGA-17-Z018	LUAD	TCGA	NRPFLMFIV	DEG_APCC_DBOX_1	0.0833
p.V383M	TCGA-24-1562	OV	TCGA	NRPFLMFIV	DEG_APCC_DBOX_1	0.2778
p.V383M	DO28412	OV	ICGC	NRPFLMFIV	DEG_APCC_DBOX_1	0.2778
p.L398I	TCGA-AX-A2HD	UCEC	TCGA	NRPFLMFIV	DEG_APCC_DBOX_1	0.1944
p.L398I	DO42608	UCEC	ICGC	NRPFLMFIV	DEG_APCC_DBOX_1	0.1944
p.R386M	TCGA-CR-7402	HNSC	TCGA	NRPFLMFIV	DEG_APCC_DBOX_1	0.8632
p.R386M	DO15727	HNSC	ICGC	NRPFLMFIV	DEG_APCC_DBOX_1	0.8632
p.N385H	TCGA-CV-A45W	HNSC	TCGA	NRPFLMFIV	DEG_APCC_DBOX_1	0.6312
p.N385H	DO52060	HNSC	ICGC	NRPFLMFIV	DEG_APCC_DBOX_1	0.6312
p.L400F	TCGA-EE-A2MS	SKCM	TCGA	NRPFLMFIV	DEG_APCC_DBOX_1	0.1389
p.L400F	DO37567	SKCM	ICGC	NRPFLMFIV	DEG_APCC_DBOX_1	0.1389
p.A375S	DO229029	LICA	ICGC	NRPFLMFIV	DEG_APCC_DBOX_1	0.0556
p.L382R	SIDM01611	Endometrial Carcinoma	GDSC	NRPFLMFIV	DEG_APCC_DBOX_1	0.25
p.L382R	ACH-000996	Endometrial/Uterine Cancer	CCLE	NRPFLMFIV	DEG_APCC_DBOX_1	0.25
p.R376H	ACH-000261	Lung Cancer	CCLE	NRPFLMFIV	DEG_APCC_DBOX_1	0.0833
p.R376H	ACH-002122	Lung Cancer	CCLE	NRPFLMFIV	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05154	Plasma serine protease inhibitor	DEG_APCC_DBOX_1	385:393	NRPFLMFIV	APC,CDC20,FZR1	0.6529	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons