DegronMD - P05160(F13B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N506K	TCGA-22-5478	LUSC	TCGA	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation rewiring degron network	0.1667
p.N506K	DO27011	LUSC	ICGC	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation rewiring degron network	0.1667
p.P497S	TCGA-60-2724	LUSC	TCGA	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation altering degron motif	0.6752
p.P497S	DO26540	LUSC	ICGC	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation altering degron motif	0.6752
p.V503L	TCGA-64-5779	LUAD	TCGA	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation rewiring degron network	0.25
p.V503L	DO24930	LUAD	ICGC	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation rewiring degron network	0.25
p.L492S	TCGA-68-7755	LUSC	TCGA	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation rewiring degron network	0.2778
p.L492S	DO26512	LUSC	ICGC	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation rewiring degron network	0.2778
p.V510A	TCGA-AJ-A8CW	UCEC	TCGA	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation rewiring degron network	0.0556
p.V510A	DO52400	UCEC	ICGC	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation rewiring degron network	0.0556
p.G508R	TCGA-D3-A8GM	SKCM	TCGA	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation rewiring degron network	0.1111
p.G508R	DO50288	SKCM	ICGC	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation rewiring degron network	0.1111
p.Q504R	TCGA-E1-A7Z3	LGG	TCGA	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation rewiring degron network	0.2222
p.Q504R	DO219805	LGG	ICGC	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation rewiring degron network	0.2222
p.D491Y	TCGA-EI-6917	READ	TCGA	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation rewiring degron network	0.25
p.D491Y	DO36881	READ	ICGC	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation rewiring degron network	0.25
p.P494L	TCGA-GN-A4U4	SKCM	TCGA	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation altering degron motif	0.6471
p.P494L	DO51256	SKCM	ICGC	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation altering degron motif	0.6471
p.L492V	TCGA-JY-A93D	ESCA	TCGA	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation rewiring degron network	0.2778
p.L492V	DO233158	GACA	ICGC	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation rewiring degron network	0.2778
p.L492V	SIDM02031	Esophageal Carcinoma	GDSC	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation rewiring degron network	0.2778
p.P494Q	DO229019	LICA	ICGC	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation altering degron motif	0.7035
p.Y490S	DO220855	MELA	ICGC	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation rewiring degron network	0.2222
p.S493F	DO222405	MELA	ICGC	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation rewiring degron network	0.3056
p.G489E	DO229470	SKCA	ICGC	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation rewiring degron network	0.1944
p.G489E	SIDM00795	Melanoma	GDSC	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation rewiring degron network	0.1944
p.G489E	ACH-000219	Skin Cancer	CCLE	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation rewiring degron network	0.1944
p.G489E	ACH-002001	Skin Cancer	CCLE	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation rewiring degron network	0.1944
p.G489E	ACH-002002	Skin Cancer	CCLE	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation rewiring degron network	0.1944
p.G489E	ACH-002003	Skin Cancer	CCLE	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation rewiring degron network	0.1944
p.G489E	A375	skin	COSMIC	PLTPLSE	DEG_SCF_FBW7_2	494:500	Mutation rewiring degron network	0.1944

Kaplan plot for F13B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

F13B

UniProt ID: P05160

Entrez ID: 2165

Protein name: Coagulation factor XIII B chain (Fibrin-stabilizing factor B subunit) (Protein-glutamine gamma-glutamyltransferase B chain) (Transglutaminase B chain)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for F13B in