DegronMD

Uniprot ID: P05160

Source protein: Coagulation factor XIII B chain

Source gene: F13B

Class: DEG_SCF_FBW7_2

Location: 494:500

E3 ligase: FBXW7

DEGRON score: 0.7511

ASA_SCORE: 78.7571

COIL: 0.7753

CONS_SCORE: 0.5027

DSS_SCORE: 0.1788

HELIX: 0.0423

FCONS_SCORE: 0.8654

RIG_SCORE: 0.7984

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N506K	TCGA-22-5478	LUSC	TCGA	PLTPLSE	DEG_SCF_FBW7_2	0.1667
p.N506K	DO27011	LUSC	ICGC	PLTPLSE	DEG_SCF_FBW7_2	0.1667
p.P497S	TCGA-60-2724	LUSC	TCGA	PLTPLSE	DEG_SCF_FBW7_2	0.6752
p.P497S	DO26540	LUSC	ICGC	PLTPLSE	DEG_SCF_FBW7_2	0.6752
p.V503L	TCGA-64-5779	LUAD	TCGA	PLTPLSE	DEG_SCF_FBW7_2	0.25
p.V503L	DO24930	LUAD	ICGC	PLTPLSE	DEG_SCF_FBW7_2	0.25
p.L492S	TCGA-68-7755	LUSC	TCGA	PLTPLSE	DEG_SCF_FBW7_2	0.2778
p.L492S	DO26512	LUSC	ICGC	PLTPLSE	DEG_SCF_FBW7_2	0.2778
p.V510A	TCGA-AJ-A8CW	UCEC	TCGA	PLTPLSE	DEG_SCF_FBW7_2	0.0556
p.V510A	DO52400	UCEC	ICGC	PLTPLSE	DEG_SCF_FBW7_2	0.0556
p.G508R	TCGA-D3-A8GM	SKCM	TCGA	PLTPLSE	DEG_SCF_FBW7_2	0.1111
p.G508R	DO50288	SKCM	ICGC	PLTPLSE	DEG_SCF_FBW7_2	0.1111
p.Q504R	TCGA-E1-A7Z3	LGG	TCGA	PLTPLSE	DEG_SCF_FBW7_2	0.2222
p.Q504R	DO219805	LGG	ICGC	PLTPLSE	DEG_SCF_FBW7_2	0.2222
p.D491Y	TCGA-EI-6917	READ	TCGA	PLTPLSE	DEG_SCF_FBW7_2	0.25
p.D491Y	DO36881	READ	ICGC	PLTPLSE	DEG_SCF_FBW7_2	0.25
p.P494L	TCGA-GN-A4U4	SKCM	TCGA	PLTPLSE	DEG_SCF_FBW7_2	0.6471
p.P494L	DO51256	SKCM	ICGC	PLTPLSE	DEG_SCF_FBW7_2	0.6471
p.L492V	TCGA-JY-A93D	ESCA	TCGA	PLTPLSE	DEG_SCF_FBW7_2	0.2778
p.L492V	DO233158	GACA	ICGC	PLTPLSE	DEG_SCF_FBW7_2	0.2778
p.L492V	SIDM02031	Esophageal Carcinoma	GDSC	PLTPLSE	DEG_SCF_FBW7_2	0.2778
p.P494Q	DO229019	LICA	ICGC	PLTPLSE	DEG_SCF_FBW7_2	0.7035
p.Y490S	DO220855	MELA	ICGC	PLTPLSE	DEG_SCF_FBW7_2	0.2222
p.S493F	DO222405	MELA	ICGC	PLTPLSE	DEG_SCF_FBW7_2	0.3056
p.G489E	DO229470	SKCA	ICGC	PLTPLSE	DEG_SCF_FBW7_2	0.1944
p.G489E	SIDM00795	Melanoma	GDSC	PLTPLSE	DEG_SCF_FBW7_2	0.1944
p.G489E	ACH-000219	Skin Cancer	CCLE	PLTPLSE	DEG_SCF_FBW7_2	0.1944
p.G489E	ACH-002001	Skin Cancer	CCLE	PLTPLSE	DEG_SCF_FBW7_2	0.1944
p.G489E	ACH-002002	Skin Cancer	CCLE	PLTPLSE	DEG_SCF_FBW7_2	0.1944
p.G489E	ACH-002003	Skin Cancer	CCLE	PLTPLSE	DEG_SCF_FBW7_2	0.1944
p.G489E	A375	skin	COSMIC	PLTPLSE	DEG_SCF_FBW7_2	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLTPLSE

Degron related mutations and impact score

Drug responses associated with F13B mutations

All proteins holding degron of PLTPLSE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05160	Coagulation factor XIII B chain	DEG_SCF_FBW7_2	494:500	PLTPLSE	FBXW7	0.7511	More...