DegronMD - P05814(CSN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S58F	TCGA-64-5781	LUAD	TCGA	IYPFVE	LIG_APCC_ABBA_1	65:70	Mutation rewiring degron network	0.1389
p.S58F	DO23740	LUAD	ICGC	IYPFVE	LIG_APCC_ABBA_1	65:70	Mutation rewiring degron network	0.1389
p.Y66N	TCGA-CR-7402	HNSC	TCGA	IYPFVE	LIG_APCC_ABBA_1	65:70	Mutation altering degron motif	0.5948
p.Y66N	DO15727	HNSC	ICGC	IYPFVE	LIG_APCC_ABBA_1	65:70	Mutation altering degron motif	0.5948
p.G75V	TCGA-D7-A6F0	STAD	TCGA	IYPFVE	LIG_APCC_ABBA_1	65:70	Mutation rewiring degron network	0.1944
p.G75V	DO50120	STAD	ICGC	IYPFVE	LIG_APCC_ABBA_1	65:70	Mutation rewiring degron network	0.1944
p.P78Q	TCGA-EE-A183	SKCM	TCGA	IYPFVE	LIG_APCC_ABBA_1	65:70	Mutation rewiring degron network	0.1111
p.P78Q	DO37715	SKCM	ICGC	IYPFVE	LIG_APCC_ABBA_1	65:70	Mutation rewiring degron network	0.1111
p.G75C	TCGA-ER-A19B	SKCM	TCGA	IYPFVE	LIG_APCC_ABBA_1	65:70	Mutation rewiring degron network	0.1944
p.G75C	DO47491	SKCM	ICGC	IYPFVE	LIG_APCC_ABBA_1	65:70	Mutation rewiring degron network	0.1944
p.P78S	TCGA-FW-A3R5	SKCM	TCGA	IYPFVE	LIG_APCC_ABBA_1	65:70	Mutation rewiring degron network	0.1111
p.P78S	DO37406	SKCM	ICGC	IYPFVE	LIG_APCC_ABBA_1	65:70	Mutation rewiring degron network	0.1111
p.P57L	TCGA-RP-A694	SKCM	TCGA	IYPFVE	LIG_APCC_ABBA_1	65:70	Mutation rewiring degron network	0.1111
p.P57L	DO51269	SKCM	ICGC	IYPFVE	LIG_APCC_ABBA_1	65:70	Mutation rewiring degron network	0.1111
p.P73S	DO222843	MELA	ICGC	IYPFVE	LIG_APCC_ABBA_1	65:70	Mutation rewiring degron network	0.25
p.P63S	SIDM02021	Esophageal Carcinoma	GDSC	IYPFVE	LIG_APCC_ABBA_1	65:70	Mutation rewiring degron network	0.2778
p.E70K	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	IYPFVE	LIG_APCC_ABBA_1	65:70	Mutation altering degron motif	0.7022
p.E70K	ACH-002215	Lymphoma	CCLE	IYPFVE	LIG_APCC_ABBA_1	65:70	Mutation altering degron motif	0.7022
p.E70K	BC-3	haematopoietic and lymphoid tissue	COSMIC	IYPFVE	LIG_APCC_ABBA_1	65:70	Mutation altering degron motif	0.7022

Kaplan plot for CSN2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CSN2

UniProt ID: P05814

Entrez ID: 1447

Protein name: Beta-casein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CSN2 in