DegronMD

Uniprot ID: P05814

Source protein: Beta-casein

Source gene: CSN2

Class: LIG_APCC_ABBA_1

Location: 65:70

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6565

ASA_SCORE: 84.15

COIL: 0.8745

CONS_SCORE: 0.6488

DSS_SCORE: 0.2398

HELIX: 0.0213

FCONS_SCORE: 0.8542

RIG_SCORE: 0.8303

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S58F	TCGA-64-5781	LUAD	TCGA	IYPFVE	LIG_APCC_ABBA_1	0.1389
p.S58F	DO23740	LUAD	ICGC	IYPFVE	LIG_APCC_ABBA_1	0.1389
p.Y66N	TCGA-CR-7402	HNSC	TCGA	IYPFVE	LIG_APCC_ABBA_1	0.5948
p.Y66N	DO15727	HNSC	ICGC	IYPFVE	LIG_APCC_ABBA_1	0.5948
p.G75V	TCGA-D7-A6F0	STAD	TCGA	IYPFVE	LIG_APCC_ABBA_1	0.1944
p.G75V	DO50120	STAD	ICGC	IYPFVE	LIG_APCC_ABBA_1	0.1944
p.P78Q	TCGA-EE-A183	SKCM	TCGA	IYPFVE	LIG_APCC_ABBA_1	0.1111
p.P78Q	DO37715	SKCM	ICGC	IYPFVE	LIG_APCC_ABBA_1	0.1111
p.G75C	TCGA-ER-A19B	SKCM	TCGA	IYPFVE	LIG_APCC_ABBA_1	0.1944
p.G75C	DO47491	SKCM	ICGC	IYPFVE	LIG_APCC_ABBA_1	0.1944
p.P78S	TCGA-FW-A3R5	SKCM	TCGA	IYPFVE	LIG_APCC_ABBA_1	0.1111
p.P78S	DO37406	SKCM	ICGC	IYPFVE	LIG_APCC_ABBA_1	0.1111
p.P57L	TCGA-RP-A694	SKCM	TCGA	IYPFVE	LIG_APCC_ABBA_1	0.1111
p.P57L	DO51269	SKCM	ICGC	IYPFVE	LIG_APCC_ABBA_1	0.1111
p.P73S	DO222843	MELA	ICGC	IYPFVE	LIG_APCC_ABBA_1	0.25
p.P63S	SIDM02021	Esophageal Carcinoma	GDSC	IYPFVE	LIG_APCC_ABBA_1	0.2778
p.E70K	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	IYPFVE	LIG_APCC_ABBA_1	0.7022
p.E70K	ACH-002215	Lymphoma	CCLE	IYPFVE	LIG_APCC_ABBA_1	0.7022
p.E70K	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	IYPFVE	LIG_APCC_ABBA_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05814	Beta-casein	LIG_APCC_ABBA_1	65:70	IYPFVE	APC,CDC20,FZR1	0.6565	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons