DegronMD - P05997(COL5A2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D754N	TCGA-34-5928	LUSC	TCGA	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation altering degron motif	0.5821
p.D754N	DO27461	LUSC	ICGC	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation altering degron motif	0.5821
p.P764R	TCGA-64-5779	LUAD	TCGA	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.0833
p.P764R	DO24930	LUAD	ICGC	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.0833
p.P764R	SIDM01746	Osteosarcoma	GDSC	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.0833
p.P764L	TCGA-AA-A017	COAD	TCGA	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.0833
p.P764L	DO7782	COAD	ICGC	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.0833
p.G756A	TCGA-AR-A5QQ	BRCA	TCGA	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.3056
p.G756A	DO44135	BRCA	ICGC	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.3056
p.G762D	TCGA-DF-A2KN	UCEC	TCGA	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.1389
p.G762D	DO223282	UCEC	ICGC	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.1389
p.G753R	TCGA-EE-A3AB	SKCM	TCGA	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation altering degron motif	0.6457
p.G753R	DO222670	MELA	ICGC	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation altering degron motif	0.6457
p.G753R	DO38057	SKCM	ICGC	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation altering degron motif	0.6457
p.D740N	TCGA-RP-A693	SKCM	TCGA	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.1111
p.D740N	DO51268	SKCM	ICGC	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.1111
p.G747N	DO222843	MELA	ICGC	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.3056
p.G765R	DO33091	PACA	ICGC	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.0556
p.G741D	SIDM02050	Colorectal Carcinoma	GDSC	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.1389
p.G756S	SIDM00516	Melanoma	GDSC	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.3056
p.G756S	ACH-002166	Skin Cancer	CCLE	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.3056
p.G756S	MZ7-mel	skin	COSMIC	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.3056
p.S745I	SIDM00410	Other Blood Cancers	GDSC	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.25
p.S745I	ACH-002317	Leukemia	CCLE	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.25
p.S745I	YT	haematopoietic and lymphoid tissue	COSMIC	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.25
p.Q761E	SIDM00077	Oral Cavity Carcinoma	GDSC	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.1667
p.Q761E	ACH-001331	Head and Neck Cancer	CCLE	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.1667
p.Q761E	BICR10	upper aerodigestive tract	COSMIC	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.1667
p.D745N	KMS-11	haematopoietic and lymphoid tissue	COSMIC	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.25
p.D751N	SKM-1	haematopoietic and lymphoid tissue	COSMIC	PSGTPGDT	DEG_SCF_FBW7_1	748:755	Mutation altering degron motif	0.6932

Kaplan plot for COL5A2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL5A2

UniProt ID: P05997

Entrez ID: 1290

Protein name: Collagen alpha-2(V) chain

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COL5A2 in