DegronMD

Uniprot ID: P05997

Source protein: Collagen alpha-2

Source gene: COL5A2

Class: DEG_SCF_FBW7_1

Location: 748:755

E3 ligase: FBXW7

DEGRON score: 0.9663

ASA_SCORE: 77.1

COIL: 0.9505

CONS_SCORE: 0.695

DSS_SCORE: 0.9108

HELIX: 0.0131

FCONS_SCORE: 0.8815

RIG_SCORE: 0.4535

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D751N	SKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	PSGTPGDT	DEG_SCF_FBW7_1	0.6932
p.G753R	TCGA-EE-A3AB	SKCM	TCGA	PSGTPGDT	DEG_SCF_FBW7_1	0.6457
p.G753R	DO222670	MELA	ICGC	PSGTPGDT	DEG_SCF_FBW7_1	0.6457
p.G753R	DO38057	SKCM	ICGC	PSGTPGDT	DEG_SCF_FBW7_1	0.6457
p.D754N	TCGA-34-5928	LUSC	TCGA	PSGTPGDT	DEG_SCF_FBW7_1	0.5821
p.D754N	DO27461	LUSC	ICGC	PSGTPGDT	DEG_SCF_FBW7_1	0.5821
p.G756A	TCGA-AR-A5QQ	BRCA	TCGA	PSGTPGDT	DEG_SCF_FBW7_1	0.3056
p.G756A	DO44135	BRCA	ICGC	PSGTPGDT	DEG_SCF_FBW7_1	0.3056
p.G747N	DO222843	MELA	ICGC	PSGTPGDT	DEG_SCF_FBW7_1	0.3056
p.G756S	SIDM00516	Melanoma	GDSC	PSGTPGDT	DEG_SCF_FBW7_1	0.3056
p.G756S	ACH-002166	Skin Cancer	CCLE	PSGTPGDT	DEG_SCF_FBW7_1	0.3056
p.G756S	MZ7-mel	skin	COSMIC	PSGTPGDT	DEG_SCF_FBW7_1	0.3056
p.S745I	SIDM00410	Other Blood Cancers	GDSC	PSGTPGDT	DEG_SCF_FBW7_1	0.25
p.S745I	ACH-002317	Leukemia	CCLE	PSGTPGDT	DEG_SCF_FBW7_1	0.25
p.S745I	YT	haematopoietic_and_lymphoid_tissue	COSMIC	PSGTPGDT	DEG_SCF_FBW7_1	0.25
p.D745N	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	PSGTPGDT	DEG_SCF_FBW7_1	0.25
p.Q761E	SIDM00077	Oral Cavity Carcinoma	GDSC	PSGTPGDT	DEG_SCF_FBW7_1	0.1667
p.Q761E	ACH-001331	Head and Neck Cancer	CCLE	PSGTPGDT	DEG_SCF_FBW7_1	0.1667
p.Q761E	BICR10	upper_aerodigestive_tract	COSMIC	PSGTPGDT	DEG_SCF_FBW7_1	0.1667
p.G762D	TCGA-DF-A2KN	UCEC	TCGA	PSGTPGDT	DEG_SCF_FBW7_1	0.1389
p.G762D	DO223282	UCEC	ICGC	PSGTPGDT	DEG_SCF_FBW7_1	0.1389
p.G741D	SIDM02050	Colorectal Carcinoma	GDSC	PSGTPGDT	DEG_SCF_FBW7_1	0.1389
p.D740N	TCGA-RP-A693	SKCM	TCGA	PSGTPGDT	DEG_SCF_FBW7_1	0.1111
p.D740N	DO51268	SKCM	ICGC	PSGTPGDT	DEG_SCF_FBW7_1	0.1111
p.P764R	TCGA-64-5779	LUAD	TCGA	PSGTPGDT	DEG_SCF_FBW7_1	0.0833

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Drug responses associated with COL5A2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PSGTPGDT

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05997	Collagen alpha-2	DEG_SCF_FBW7_1	748:755	PSGTPGDT	FBXW7	0.9663	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSGTPGDT

Degron related mutations and impact score

Drug responses associated with COL5A2 mutations

All proteins holding degron of PSGTPGDT