DegronMD

Uniprot ID: P05997

Source protein: Collagen alpha-2

Source gene: COL5A2

Class: DEG_SCF_FBW7_1

Location: 748:755

E3 ligase: FBXW7

DEGRON score: 0.9663

ASA_SCORE: 77.1

COIL: 0.9505

CONS_SCORE: 0.695

DSS_SCORE: 0.9108

HELIX: 0.0131

FCONS_SCORE: 0.8815

RIG_SCORE: 0.4535

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D754N	TCGA-34-5928	LUSC	TCGA	PSGTPGDT	DEG_SCF_FBW7_1	0.5821
p.D754N	DO27461	LUSC	ICGC	PSGTPGDT	DEG_SCF_FBW7_1	0.5821
p.P764R	TCGA-64-5779	LUAD	TCGA	PSGTPGDT	DEG_SCF_FBW7_1	0.0833
p.P764R	DO24930	LUAD	ICGC	PSGTPGDT	DEG_SCF_FBW7_1	0.0833
p.P764R	SIDM01746	Osteosarcoma	GDSC	PSGTPGDT	DEG_SCF_FBW7_1	0.0833
p.P764L	TCGA-AA-A017	COAD	TCGA	PSGTPGDT	DEG_SCF_FBW7_1	0.0833
p.P764L	DO7782	COAD	ICGC	PSGTPGDT	DEG_SCF_FBW7_1	0.0833
p.G756A	TCGA-AR-A5QQ	BRCA	TCGA	PSGTPGDT	DEG_SCF_FBW7_1	0.3056
p.G756A	DO44135	BRCA	ICGC	PSGTPGDT	DEG_SCF_FBW7_1	0.3056
p.G762D	TCGA-DF-A2KN	UCEC	TCGA	PSGTPGDT	DEG_SCF_FBW7_1	0.1389
p.G762D	DO223282	UCEC	ICGC	PSGTPGDT	DEG_SCF_FBW7_1	0.1389
p.G753R	TCGA-EE-A3AB	SKCM	TCGA	PSGTPGDT	DEG_SCF_FBW7_1	0.6457
p.G753R	DO222670	MELA	ICGC	PSGTPGDT	DEG_SCF_FBW7_1	0.6457
p.G753R	DO38057	SKCM	ICGC	PSGTPGDT	DEG_SCF_FBW7_1	0.6457
p.D740N	TCGA-RP-A693	SKCM	TCGA	PSGTPGDT	DEG_SCF_FBW7_1	0.1111
p.D740N	DO51268	SKCM	ICGC	PSGTPGDT	DEG_SCF_FBW7_1	0.1111
p.G747N	DO222843	MELA	ICGC	PSGTPGDT	DEG_SCF_FBW7_1	0.3056
p.G765R	DO33091	PACA	ICGC	PSGTPGDT	DEG_SCF_FBW7_1	0.0556
p.G741D	SIDM02050	Colorectal Carcinoma	GDSC	PSGTPGDT	DEG_SCF_FBW7_1	0.1389
p.G756S	SIDM00516	Melanoma	GDSC	PSGTPGDT	DEG_SCF_FBW7_1	0.3056
p.G756S	ACH-002166	Skin Cancer	CCLE	PSGTPGDT	DEG_SCF_FBW7_1	0.3056
p.G756S	MZ7-mel	skin	COSMIC	PSGTPGDT	DEG_SCF_FBW7_1	0.3056
p.S745I	SIDM00410	Other Blood Cancers	GDSC	PSGTPGDT	DEG_SCF_FBW7_1	0.25
p.S745I	ACH-002317	Leukemia	CCLE	PSGTPGDT	DEG_SCF_FBW7_1	0.25
p.S745I	YT	haematopoietic_and_lymphoid_tissue	COSMIC	PSGTPGDT	DEG_SCF_FBW7_1	0.25
p.Q761E	SIDM00077	Oral Cavity Carcinoma	GDSC	PSGTPGDT	DEG_SCF_FBW7_1	0.1667
p.Q761E	ACH-001331	Head and Neck Cancer	CCLE	PSGTPGDT	DEG_SCF_FBW7_1	0.1667
p.Q761E	BICR10	upper_aerodigestive_tract	COSMIC	PSGTPGDT	DEG_SCF_FBW7_1	0.1667
p.D745N	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	PSGTPGDT	DEG_SCF_FBW7_1	0.25
p.D751N	SKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	PSGTPGDT	DEG_SCF_FBW7_1	0.6932

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSGTPGDT

Degron related mutations and impact score

Drug responses associated with COL5A2 mutations

All proteins holding degron of PSGTPGDT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05997	Collagen alpha-2	DEG_SCF_FBW7_1	748:755	PSGTPGDT	FBXW7	0.9663	More...