DegronMD - P06401(PGR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D116E	TCGA-06-0192	GBM	TCGA	DSGLLDS	DEG_SCF_TRCP1_1	107:113	Mutation rewiring degron network	0.25
p.D116E	DO13420	GBM	ICGC	DSGLLDS	DEG_SCF_TRCP1_1	107:113	Mutation rewiring degron network	0.25
p.S102I	TCGA-21-1083	LUSC	TCGA	DSGLLDS	DEG_SCF_TRCP1_1	107:113	Mutation blocking phosphorylation signal	0.6389
p.S102I	DO26769	LUSC	ICGC	DSGLLDS	DEG_SCF_TRCP1_1	107:113	Mutation blocking phosphorylation signal	0.6389
p.S101C	TCGA-77-7463	LUSC	TCGA	DSGLLDS	DEG_SCF_TRCP1_1	107:113	Mutation blocking phosphorylation signal	0.6111
p.S101C	DO26716	LUSC	ICGC	DSGLLDS	DEG_SCF_TRCP1_1	107:113	Mutation blocking phosphorylation signal	0.6111
p.S108I	TCGA-BR-7703	STAD	TCGA	DSGLLDS	DEG_SCF_TRCP1_1	107:113	Mutation altering degron motif	0.7341
p.S108I	DO38232	STAD	ICGC	DSGLLDS	DEG_SCF_TRCP1_1	107:113	Mutation altering degron motif	0.7341
p.G109R	TCGA-F4-6570	COAD	TCGA	DSGLLDS	DEG_SCF_TRCP1_1	107:113	Mutation altering degron motif	0.7568
p.G109R	DO10443	COAD	ICGC	DSGLLDS	DEG_SCF_TRCP1_1	107:113	Mutation altering degron motif	0.7568
p.A120V	SIDM00254	Neuroblastoma	GDSC	DSGLLDS	DEG_SCF_TRCP1_1	107:113	Mutation rewiring degron network	0.1389
p.A120V	SIDM01318	Hepatocellular Carcinoma	GDSC	DSGLLDS	DEG_SCF_TRCP1_1	107:113	Mutation rewiring degron network	0.1389
p.S99I	ECC10	stomach	COSMIC	DSGLLDS	DEG_SCF_TRCP1_1	107:113	Mutation rewiring degron network	0.1111
p.H109Y	SNU-175	large intestine	COSMIC	DSGLLDS	DEG_SCF_TRCP1_1	107:113	Mutation altering degron motif	0.7229
p.D103Y	NCI-H2126	lung	COSMIC	DSGLLDS	DEG_SCF_TRCP1_1	107:113	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons