DegronMD

Uniprot ID: P06401

Source protein: Progesterone receptor

Source gene: PGR

Class: DEG_SCF_TRCP1_1

Location: 107:113

E3 ligase: BTRC

DEGRON score: 0.8687

ASA_SCORE: 57.3857

COIL: 0.5603

CONS_SCORE: 0.4092

DSS_SCORE: 0.6728

HELIX: 0.373

FCONS_SCORE: 1.1395

RIG_SCORE: 0.6672

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D116E	TCGA-06-0192	GBM	TCGA	DSGLLDS	DEG_SCF_TRCP1_1	0.25
p.D116E	DO13420	GBM	ICGC	DSGLLDS	DEG_SCF_TRCP1_1	0.25
p.S102I	TCGA-21-1083	LUSC	TCGA	DSGLLDS	DEG_SCF_TRCP1_1	0.6389
p.S102I	DO26769	LUSC	ICGC	DSGLLDS	DEG_SCF_TRCP1_1	0.6389
p.S101C	TCGA-77-7463	LUSC	TCGA	DSGLLDS	DEG_SCF_TRCP1_1	0.6111
p.S101C	DO26716	LUSC	ICGC	DSGLLDS	DEG_SCF_TRCP1_1	0.6111
p.S108I	TCGA-BR-7703	STAD	TCGA	DSGLLDS	DEG_SCF_TRCP1_1	0.7341
p.S108I	DO38232	STAD	ICGC	DSGLLDS	DEG_SCF_TRCP1_1	0.7341
p.G109R	TCGA-F4-6570	COAD	TCGA	DSGLLDS	DEG_SCF_TRCP1_1	0.7568
p.G109R	DO10443	COAD	ICGC	DSGLLDS	DEG_SCF_TRCP1_1	0.7568
p.A120V	SIDM00254	Neuroblastoma	GDSC	DSGLLDS	DEG_SCF_TRCP1_1	0.1389
p.A120V	SIDM01318	Hepatocellular Carcinoma	GDSC	DSGLLDS	DEG_SCF_TRCP1_1	0.1389
p.S99I	ECC10	stomach	COSMIC	DSGLLDS	DEG_SCF_TRCP1_1	0.1111
p.H109Y	SNU-175	large_intestine	COSMIC	DSGLLDS	DEG_SCF_TRCP1_1	0.7229
p.D103Y	NCI-H2126	lung	COSMIC	DSGLLDS	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P06401	Progesterone receptor	DEG_SCF_TRCP1_1	107:113	DSGLLDS	BTRC	0.8687	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons