DegronMD - P07101(TH)

GO - Biological processes (BP): aminergic neurotransmitter loading into synaptic vesicle [GO:0015842]; anatomical structure morphogenesis [GO:0009653]; animal organ morphogenesis [GO:0009887]; cellular response to alkaloid [GO:0071312]; cellular response to glucose stimulus [GO:0071333]; cellular response to growth factor stimulus [GO:0071363]; cellular response to manganese ion [GO:0071287]; cellular response to nicotine [GO:0071316]; cellular response to xenobiotic stimulus [GO:0071466]; cerebral cortex development [GO:0021987]; circadian sleep/wake cycle [GO:0042745]; dopamine biosynthetic process [GO:0042416]; dopamine biosynthetic process from tyrosine [GO:0006585]; eating behavior [GO:0042755]; embryonic camera-type eye morphogenesis [GO:0048596]; epinephrine biosynthetic process [GO:0042418]; eye photoreceptor cell development [GO:0042462]; fatty acid metabolic process [GO:0006631]; glycoside metabolic process [GO:0016137]; heart development [GO:0007507]; heart morphogenesis [GO:0003007]; hyaloid vascular plexus regression [GO:1990384]; isoquinoline alkaloid metabolic process [GO:0033076]; learning [GO:0007612]; locomotory behavior [GO:0007626]; mating behavior [GO:0007617]; memory [GO:0007613]; multicellular organism aging [GO:0010259]; neurotransmitter biosynthetic process [GO:0042136]; norepinephrine biosynthetic process [GO:0042421]; phthalate metabolic process [GO:0018963]; phytoalexin metabolic process [GO:0052314]; pigmentation [GO:0043473]; regulation of heart contraction [GO:0008016]; response to activity [GO:0014823]; response to amphetamine [GO:0001975]; response to corticosterone [GO:0051412]; response to electrical stimulus [GO:0051602]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to ether [GO:0045472]; response to herbicide [GO:0009635]; response to hypoxia [GO:0001666]; response to immobilization stress [GO:0035902]; response to isolation stress [GO:0035900]; response to light stimulus [GO:0009416]; response to lipopolysaccharide [GO:0032496]; response to nutrient levels [GO:0031667]; response to peptide hormone [GO:0043434]; response to pyrethroid [GO:0046684]; response to salt stress [GO:0009651]; response to water deprivation [GO:0009414]; response to zinc ion [GO:0010043]; sensory perception of sound [GO:0007605]; social behavior [GO:0035176]; sphingolipid metabolic process [GO:0006665]; synaptic transmission, dopaminergic [GO:0001963]; terpene metabolic process [GO:0042214]; visual perception [GO:0007601] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P4L	TCGA-FW-A3R5	SKCM	TCGA	MPTPDAT	DEG_SCF_FBW7_1	1:7	Mutation altering degron motif	0.7582
p.P4L	DO37406	SKCM	ICGC	MPTPDAT	DEG_SCF_FBW7_1	1:7	Mutation altering degron motif	0.7582
p.P4L	SIDM00422	Hodgkin's Lymphoma	GDSC	MPTPDAT	DEG_SCF_FBW7_1	1:7	Mutation altering degron motif	0.7582
p.P4L	ACH-001203	Lymphoma	CCLE	MPTPDAT	DEG_SCF_FBW7_1	1:7	Mutation altering degron motif	0.7582
p.P4L	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	MPTPDAT	DEG_SCF_FBW7_1	1:7	Mutation altering degron motif	0.7582
p.R15H	TCGA-NC-A5HH	LUSC	TCGA	MPTPDAT	DEG_SCF_FBW7_1	1:7	Mutation rewiring degron network	0.1111
p.R15H	DO219187	LUSC	ICGC	MPTPDAT	DEG_SCF_FBW7_1	1:7	Mutation rewiring degron network	0.1111
p.R15H	SIDM00217	Colorectal Carcinoma	GDSC	MPTPDAT	DEG_SCF_FBW7_1	1:7	Mutation rewiring degron network	0.1111
p.R15H	SIDM01398	Melanoma	GDSC	MPTPDAT	DEG_SCF_FBW7_1	1:7	Mutation rewiring degron network	0.1111
p.R15H	SNU-1040	large intestine	COSMIC	MPTPDAT	DEG_SCF_FBW7_1	1:7	Mutation rewiring degron network	0.1111
p.K12R	DO227988	COCA	ICGC	MPTPDAT	DEG_SCF_FBW7_1	1:7	Mutation substituting flanking lysine	0.3056
p.P9Q	DO229008	LICA	ICGC	MPTPDAT	DEG_SCF_FBW7_1	1:7	Mutation rewiring degron network	0.2778
p.Q10R	DO229211	THCA	ICGC	MPTPDAT	DEG_SCF_FBW7_1	1:7	Mutation rewiring degron network	0.25
p.A6P	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	MPTPDAT	DEG_SCF_FBW7_1	1:7	Mutation altering degron motif	0.6392
p.A6P	NCI-H1793	lung	COSMIC	MPTPDAT	DEG_SCF_FBW7_1	1:7	Mutation altering degron motif	0.6392
p.A17V	SIDM01424	B-Lymphoblastic Leukemia	GDSC	MPTPDAT	DEG_SCF_FBW7_1	1:7	Mutation rewiring degron network	0.0556
p.A17V	ACH-000782	Leukemia	CCLE	MPTPDAT	DEG_SCF_FBW7_1	1:7	Mutation rewiring degron network	0.0556
p.A17V	ACH-001735	Leukemia	CCLE	MPTPDAT	DEG_SCF_FBW7_1	1:7	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TH

UniProt ID: P07101

Entrez ID: 7054

Protein name: Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TH in