DegronMD

Uniprot ID: P07101

Source protein: Tyrosine 3-monooxygenase

Source gene: TH

Class: DEG_SCF_FBW7_1

Location: 1:7

E3 ligase: FBXW7

DEGRON score: 0.9948

ASA_SCORE: 89.8143

COIL: 0.9394

CONS_SCORE: 0.3135

DSS_SCORE: 0.9335

HELIX: 0.0481

FCONS_SCORE: 1.1016

RIG_SCORE: 0.6662

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P4L	TCGA-FW-A3R5	SKCM	TCGA	MPTPDAT	DEG_SCF_FBW7_1	0.7582
p.P4L	DO37406	SKCM	ICGC	MPTPDAT	DEG_SCF_FBW7_1	0.7582
p.P4L	SIDM00422	Hodgkin's Lymphoma	GDSC	MPTPDAT	DEG_SCF_FBW7_1	0.7582
p.P4L	ACH-001203	Lymphoma	CCLE	MPTPDAT	DEG_SCF_FBW7_1	0.7582
p.P4L	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	MPTPDAT	DEG_SCF_FBW7_1	0.7582
p.R15H	TCGA-NC-A5HH	LUSC	TCGA	MPTPDAT	DEG_SCF_FBW7_1	0.1111
p.R15H	DO219187	LUSC	ICGC	MPTPDAT	DEG_SCF_FBW7_1	0.1111
p.R15H	SIDM00217	Colorectal Carcinoma	GDSC	MPTPDAT	DEG_SCF_FBW7_1	0.1111
p.R15H	SIDM01398	Melanoma	GDSC	MPTPDAT	DEG_SCF_FBW7_1	0.1111
p.R15H	SNU-1040	large_intestine	COSMIC	MPTPDAT	DEG_SCF_FBW7_1	0.1111
p.K12R	DO227988	COCA	ICGC	MPTPDAT	DEG_SCF_FBW7_1	0.3056
p.P9Q	DO229008	LICA	ICGC	MPTPDAT	DEG_SCF_FBW7_1	0.2778
p.Q10R	DO229211	THCA	ICGC	MPTPDAT	DEG_SCF_FBW7_1	0.25
p.A6P	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	MPTPDAT	DEG_SCF_FBW7_1	0.6392
p.A6P	NCI-H1793	lung	COSMIC	MPTPDAT	DEG_SCF_FBW7_1	0.6392
p.A17V	SIDM01424	B-Lymphoblastic Leukemia	GDSC	MPTPDAT	DEG_SCF_FBW7_1	0.0556
p.A17V	ACH-000782	Leukemia	CCLE	MPTPDAT	DEG_SCF_FBW7_1	0.0556
p.A17V	ACH-001735	Leukemia	CCLE	MPTPDAT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07101	Tyrosine 3-monooxygenase	DEG_SCF_FBW7_1	1:7	MPTPDAT	FBXW7	0.9948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons