DegronMD - P07199(CENPB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D529N	TCGA-A5-A0G2	UCEC	TCGA	DEEDGDEVPVPSF	DEG_COP1_1	532:544	Mutation rewiring degron network	0.25
p.D529N	TCGA-AG-3902	READ	TCGA	DEEDGDEVPVPSF	DEG_COP1_1	532:544	Mutation rewiring degron network	0.25
p.D529N	TCGA-EO-A22R	UCEC	TCGA	DEEDGDEVPVPSF	DEG_COP1_1	532:544	Mutation rewiring degron network	0.25
p.D529N	DO36407	READ	ICGC	DEEDGDEVPVPSF	DEG_COP1_1	532:544	Mutation rewiring degron network	0.25
p.D529N	DO41235	UCEC	ICGC	DEEDGDEVPVPSF	DEG_COP1_1	532:544	Mutation rewiring degron network	0.25
p.D529N	DO42713	UCEC	ICGC	DEEDGDEVPVPSF	DEG_COP1_1	532:544	Mutation rewiring degron network	0.25
p.A549T	TCGA-A5-A2K7	UCEC	TCGA	DEEDGDEVPVPSF	DEG_COP1_1	532:544	Mutation rewiring degron network	0.1944
p.A549T	DO41271	UCEC	ICGC	DEEDGDEVPVPSF	DEG_COP1_1	532:544	Mutation rewiring degron network	0.1944
p.A549T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	DEEDGDEVPVPSF	DEG_COP1_1	532:544	Mutation rewiring degron network	0.1944
p.A549T	ACH-001127	Leukemia	CCLE	DEEDGDEVPVPSF	DEG_COP1_1	532:544	Mutation rewiring degron network	0.1944
p.A549T	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	DEEDGDEVPVPSF	DEG_COP1_1	532:544	Mutation rewiring degron network	0.1944
p.G545V	TCGA-D3-A1QA	SKCM	TCGA	DEEDGDEVPVPSF	DEG_COP1_1	532:544	Mutation rewiring degron network	0.3056
p.G545V	DO47469	SKCM	ICGC	DEEDGDEVPVPSF	DEG_COP1_1	532:544	Mutation rewiring degron network	0.3056
p.D530N	TCGA-FI-A2D5	UCEC	TCGA	DEEDGDEVPVPSF	DEG_COP1_1	532:544	Mutation rewiring degron network	0.2778
p.D530N	DO41331	UCEC	ICGC	DEEDGDEVPVPSF	DEG_COP1_1	532:544	Mutation rewiring degron network	0.2778
p.D524E	TCGA-GN-A8LL	SKCM	TCGA	DEEDGDEVPVPSF	DEG_COP1_1	532:544	Mutation rewiring degron network	0.1111
p.D524E	DO51261	SKCM	ICGC	DEEDGDEVPVPSF	DEG_COP1_1	532:544	Mutation rewiring degron network	0.1111
p.E538Q	TCGA-VS-A953	CESC	TCGA	DEEDGDEVPVPSF	DEG_COP1_1	532:544	Mutation altering degron motif	0.5633
p.E538Q	DO219727	CESC	ICGC	DEEDGDEVPVPSF	DEG_COP1_1	532:544	Mutation altering degron motif	0.5633
p.E533V	DO231992	LICA	ICGC	DEEDGDEVPVPSF	DEG_COP1_1	532:544	Mutation altering degron motif	0.7693
p.E533D	SIDM00845	Burkitt's Lymphoma	GDSC	DEEDGDEVPVPSF	DEG_COP1_1	532:544	Mutation altering degron motif	0.5647

Kaplan plot for CENPB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CENPB

UniProt ID: P07199

Entrez ID: 1059

Protein name: Major centromere autoantigen B (Centromere protein B) (CENP-B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CENPB in