DegronMD

Uniprot ID: P07199

Source protein: Major centromere autoantigen B

Source gene: CENPB

Class: DEG_COP1_1

Location: 532:544

E3 ligase: COP1

DEGRON score: 0.9042

ASA_SCORE: 83.8308

COIL: 0.8491

CONS_SCORE: 0.356

DSS_SCORE: 0.8495

HELIX: 0.1168

FCONS_SCORE: 1.1224

RIG_SCORE: 0.6757

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D529N	TCGA-A5-A0G2	UCEC	TCGA	DEEDGDEVPVPSF	DEG_COP1_1	0.25
p.D529N	TCGA-AG-3902	READ	TCGA	DEEDGDEVPVPSF	DEG_COP1_1	0.25
p.D529N	TCGA-EO-A22R	UCEC	TCGA	DEEDGDEVPVPSF	DEG_COP1_1	0.25
p.D529N	DO36407	READ	ICGC	DEEDGDEVPVPSF	DEG_COP1_1	0.25
p.D529N	DO41235	UCEC	ICGC	DEEDGDEVPVPSF	DEG_COP1_1	0.25
p.D529N	DO42713	UCEC	ICGC	DEEDGDEVPVPSF	DEG_COP1_1	0.25
p.A549T	TCGA-A5-A2K7	UCEC	TCGA	DEEDGDEVPVPSF	DEG_COP1_1	0.1944
p.A549T	DO41271	UCEC	ICGC	DEEDGDEVPVPSF	DEG_COP1_1	0.1944
p.A549T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	DEEDGDEVPVPSF	DEG_COP1_1	0.1944
p.A549T	ACH-001127	Leukemia	CCLE	DEEDGDEVPVPSF	DEG_COP1_1	0.1944
p.A549T	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	DEEDGDEVPVPSF	DEG_COP1_1	0.1944
p.G545V	TCGA-D3-A1QA	SKCM	TCGA	DEEDGDEVPVPSF	DEG_COP1_1	0.3056
p.G545V	DO47469	SKCM	ICGC	DEEDGDEVPVPSF	DEG_COP1_1	0.3056
p.D530N	TCGA-FI-A2D5	UCEC	TCGA	DEEDGDEVPVPSF	DEG_COP1_1	0.2778
p.D530N	DO41331	UCEC	ICGC	DEEDGDEVPVPSF	DEG_COP1_1	0.2778
p.D524E	TCGA-GN-A8LL	SKCM	TCGA	DEEDGDEVPVPSF	DEG_COP1_1	0.1111
p.D524E	DO51261	SKCM	ICGC	DEEDGDEVPVPSF	DEG_COP1_1	0.1111
p.E538Q	TCGA-VS-A953	CESC	TCGA	DEEDGDEVPVPSF	DEG_COP1_1	0.5633
p.E538Q	DO219727	CESC	ICGC	DEEDGDEVPVPSF	DEG_COP1_1	0.5633
p.E533V	DO231992	LICA	ICGC	DEEDGDEVPVPSF	DEG_COP1_1	0.7693
p.E533D	SIDM00845	Burkitt's Lymphoma	GDSC	DEEDGDEVPVPSF	DEG_COP1_1	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07199	Major centromere autoantigen B	DEG_COP1_1	532:544	DEEDGDEVPVPSF	COP1	0.9042	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons