DegronMD - P07237(P4HB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E280D	TCGA-28-2506	GBM	TCGA	LFIFID	LIG_APCC_ABBA_1	287:292	Mutation rewiring degron network	0.1389
p.E280D	DO11585	GBM	ICGC	LFIFID	LIG_APCC_ABBA_1	287:292	Mutation rewiring degron network	0.1389
p.L287M	TCGA-AY-6197	COAD	TCGA	LFIFID	LIG_APCC_ABBA_1	287:292	Mutation altering degron motif	0.5999
p.L287M	DO9956	COAD	ICGC	LFIFID	LIG_APCC_ABBA_1	287:292	Mutation altering degron motif	0.5999
p.R300H	TCGA-BK-A6W3	UCEC	TCGA	LFIFID	LIG_APCC_ABBA_1	287:292	Mutation rewiring degron network	0.1111
p.R300H	TCGA-BR-6452	STAD	TCGA	LFIFID	LIG_APCC_ABBA_1	287:292	Mutation rewiring degron network	0.1111
p.R300H	DO38404	STAD	ICGC	LFIFID	LIG_APCC_ABBA_1	287:292	Mutation rewiring degron network	0.1111
p.R300H	DO50076	UCEC	ICGC	LFIFID	LIG_APCC_ABBA_1	287:292	Mutation rewiring degron network	0.1111
p.R300H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LFIFID	LIG_APCC_ABBA_1	287:292	Mutation rewiring degron network	0.1111
p.R300H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	LFIFID	LIG_APCC_ABBA_1	287:292	Mutation rewiring degron network	0.1111
p.S293R	DO229019	LICA	ICGC	LFIFID	LIG_APCC_ABBA_1	287:292	Mutation blocking phosphorylation signal	0.75
p.N298K	DO229015	LICA	ICGC	LFIFID	LIG_APCC_ABBA_1	287:292	Mutation rewiring degron network	0.1667
p.F288L	DO229045	LICA	ICGC	LFIFID	LIG_APCC_ABBA_1	287:292	Mutation altering degron motif	0.587
p.E280K	SIDM00101	Mesothelioma	GDSC	LFIFID	LIG_APCC_ABBA_1	287:292	Mutation rewiring degron network	0.1389
p.E280K	H2591	pleura	COSMIC	LFIFID	LIG_APCC_ABBA_1	287:292	Mutation rewiring degron network	0.1389
p.D292N	SIDM01561	Melanoma	GDSC	LFIFID	LIG_APCC_ABBA_1	287:292	Mutation altering degron motif	0.6932
p.R301L	ACH-000551	Leukemia	CCLE	LFIFID	LIG_APCC_ABBA_1	287:292	Mutation rewiring degron network	0.0833
p.R301L	ACH-002061	Leukemia	CCLE	LFIFID	LIG_APCC_ABBA_1	287:292	Mutation rewiring degron network	0.0833
p.R301L	K-562	haematopoietic and lymphoid tissue	COSMIC	LFIFID	LIG_APCC_ABBA_1	287:292	Mutation rewiring degron network	0.0833
p.K282T	ACH-000970	Colon/Colorectal Cancer	CCLE	LFIFID	LIG_APCC_ABBA_1	287:292	Mutation rewiring degron network	0.1944
p.K282T	SNU-C5	large intestine	COSMIC	LFIFID	LIG_APCC_ABBA_1	287:292	Mutation rewiring degron network	0.1944
p.E289D	ACH-001399	Colon/Colorectal Cancer	CCLE	LFIFID	LIG_APCC_ABBA_1	287:292	Mutation altering degron motif	0.6758
p.E289D	SW626	ovary	COSMIC	LFIFID	LIG_APCC_ABBA_1	287:292	Mutation altering degron motif	0.6758

Kaplan plot for P4HB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

P4HB

UniProt ID: P07237

Entrez ID: 5034

Protein name: Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for P4HB in