DegronMD

Uniprot ID: P07237

Source protein: Protein disulfide-isomerase

Source gene: P4HB

Class: LIG_APCC_ABBA_1

Location: 287:292

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5916

ASA_SCORE: 11.7

COIL: 0.0527

CONS_SCORE: 0.4611

DSS_SCORE: 0.097

HELIX: 0.0082

FCONS_SCORE: 1.1953

RIG_SCORE: 0.9315

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E280D	TCGA-28-2506	GBM	TCGA	LFIFID	LIG_APCC_ABBA_1	0.1389
p.E280D	DO11585	GBM	ICGC	LFIFID	LIG_APCC_ABBA_1	0.1389
p.L287M	TCGA-AY-6197	COAD	TCGA	LFIFID	LIG_APCC_ABBA_1	0.5999
p.L287M	DO9956	COAD	ICGC	LFIFID	LIG_APCC_ABBA_1	0.5999
p.R300H	TCGA-BK-A6W3	UCEC	TCGA	LFIFID	LIG_APCC_ABBA_1	0.1111
p.R300H	TCGA-BR-6452	STAD	TCGA	LFIFID	LIG_APCC_ABBA_1	0.1111
p.R300H	DO38404	STAD	ICGC	LFIFID	LIG_APCC_ABBA_1	0.1111
p.R300H	DO50076	UCEC	ICGC	LFIFID	LIG_APCC_ABBA_1	0.1111
p.R300H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LFIFID	LIG_APCC_ABBA_1	0.1111
p.R300H	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LFIFID	LIG_APCC_ABBA_1	0.1111
p.S293R	DO229019	LICA	ICGC	LFIFID	LIG_APCC_ABBA_1	0.75
p.N298K	DO229015	LICA	ICGC	LFIFID	LIG_APCC_ABBA_1	0.1667
p.F288L	DO229045	LICA	ICGC	LFIFID	LIG_APCC_ABBA_1	0.587
p.E280K	SIDM00101	Mesothelioma	GDSC	LFIFID	LIG_APCC_ABBA_1	0.1389
p.E280K	H2591	pleura	COSMIC	LFIFID	LIG_APCC_ABBA_1	0.1389
p.D292N	SIDM01561	Melanoma	GDSC	LFIFID	LIG_APCC_ABBA_1	0.6932
p.R301L	ACH-000551	Leukemia	CCLE	LFIFID	LIG_APCC_ABBA_1	0.0833
p.R301L	ACH-002061	Leukemia	CCLE	LFIFID	LIG_APCC_ABBA_1	0.0833
p.R301L	K-562	haematopoietic_and_lymphoid_tissue	COSMIC	LFIFID	LIG_APCC_ABBA_1	0.0833
p.K282T	ACH-000970	Colon/Colorectal Cancer	CCLE	LFIFID	LIG_APCC_ABBA_1	0.1944
p.K282T	SNU-C5	large_intestine	COSMIC	LFIFID	LIG_APCC_ABBA_1	0.1944
p.E289D	ACH-001399	Colon/Colorectal Cancer	CCLE	LFIFID	LIG_APCC_ABBA_1	0.6758
p.E289D	SW626	ovary	COSMIC	LFIFID	LIG_APCC_ABBA_1	0.6758

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07237	Protein disulfide-isomerase	LIG_APCC_ABBA_1	287:292	LFIFID	APC,CDC20,FZR1	0.5916	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons