DegronMD - P07711(CTSL)

FUNCTION: Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Plays a critical for normal cellular functions such as general protein turnover, antigen processing and bone remodeling. Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter (By similarity). In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells. Also mediates invariant chain processing in cortical thymic epithelial cells (By similarity). Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (By similarity). Secreted form generates endostatin from COL18A1 (PubMed:10716919). Critical for cardiac morphology and function. Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (By similarity). Required for maximal stimulation of steroidogenesis by TIMP1 (By similarity). {ECO:0000250|UniProtKB:P06797, ECO:0000250|UniProtKB:P07154, ECO:0000250|UniProtKB:P25975, ECO:0000269|PubMed:10716919, ECO:0000305}.; FUNCTION: [Isoform 2]: Functions in the regulation of cell cycle progression through proteolytic processing of the CUX1 transcription factor (PubMed:15099520). Translation initiation at downstream start sites allows the synthesis of isoforms that are devoid of a signal peptide and localize to the nucleus where they cleave the CUX1 transcription factor and modify its DNA binding properties (PubMed:15099520). {ECO:0000269|PubMed:15099520}.; FUNCTION: (Microbial infection) In cells lacking TMPRSS2 expression, facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via a slow acid-activated route with the proteolysis of coronavirus spike (S) glycoproteins in lysosome for entry into host cell (PubMed:32142651, PubMed:32221306, PubMed:16339146, PubMed:18562523). Proteolysis within lysosomes is sufficient to activate membrane fusion by coronaviruses SARS-CoV and EMC (HCoV-EMC) S as well as Zaire ebolavirus glycoproteins (PubMed:16081529, PubMed:26953343, PubMed:18562523). {ECO:0000269|PubMed:16081529, ECO:0000269|PubMed:16339146, ECO:0000269|PubMed:18562523, ECO:0000269|PubMed:26953343, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32221306, ECO:0000269|PubMed:32855215}. View more >>

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R98H	TCGA-AX-A2HA	UCEC	TCGA	KGKVFQE	LIG_APCC_ABBAyCdc20_2	102:108	Mutation rewiring degron network	0.2222
p.R98H	DO42504	UCEC	ICGC	KGKVFQE	LIG_APCC_ABBAyCdc20_2	102:108	Mutation rewiring degron network	0.2222
p.R98H	ACH-001068	Lymphoma	CCLE	KGKVFQE	LIG_APCC_ABBAyCdc20_2	102:108	Mutation rewiring degron network	0.2222
p.G103V	TCGA-DA-A1I1	SKCM	TCGA	KGKVFQE	LIG_APCC_ABBAyCdc20_2	102:108	Mutation altering degron motif	0.6421
p.G103V	TCGA-FS-A1ZR	SKCM	TCGA	KGKVFQE	LIG_APCC_ABBAyCdc20_2	102:108	Mutation altering degron motif	0.6421
p.G103V	DO37651	SKCM	ICGC	KGKVFQE	LIG_APCC_ABBAyCdc20_2	102:108	Mutation altering degron motif	0.6421
p.G103V	DO37966	SKCM	ICGC	KGKVFQE	LIG_APCC_ABBAyCdc20_2	102:108	Mutation altering degron motif	0.6421
p.E113A	TCGA-EB-A3Y6	SKCM	TCGA	KGKVFQE	LIG_APCC_ABBAyCdc20_2	102:108	Mutation rewiring degron network	0.1944
p.E113A	DO38081	SKCM	ICGC	KGKVFQE	LIG_APCC_ABBAyCdc20_2	102:108	Mutation rewiring degron network	0.1944
p.R98C	DO233673	GACA	ICGC	KGKVFQE	LIG_APCC_ABBAyCdc20_2	102:108	Mutation rewiring degron network	0.2222
p.S117Y	SIDM00773	Non-Cancerous	GDSC	KGKVFQE	LIG_APCC_ABBAyCdc20_2	102:108	Mutation rewiring degron network	0.0833
p.S117Y	SIDM00774	Breast Carcinoma	GDSC	KGKVFQE	LIG_APCC_ABBAyCdc20_2	102:108	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CTSL

UniProt ID: P07711

Entrez ID: 1514

Protein name: Procathepsin L (EC 3.4.22.15) (Cathepsin L1) (Major excreted protein) (MEP) [Cleaved into: Cathepsin L; Cathepsin L heavy chain; Cathepsin L light chain]

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CTSL in