DegronMD

Uniprot ID: P07711

Source protein: Procathepsin L

Source gene: CTSL

Class: LIG_APCC_ABBAyCdc20_2

Location: 102:108

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9333

ASA_SCORE: 94.2571

COIL: 0.7481

CONS_SCORE: 0.3333

DSS_SCORE: 0.4135

HELIX: 0.0201

FCONS_SCORE: 0.7995

RIG_SCORE: 0.7785

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R98H	TCGA-AX-A2HA	UCEC	TCGA	KGKVFQE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R98H	DO42504	UCEC	ICGC	KGKVFQE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R98H	ACH-001068	Lymphoma	CCLE	KGKVFQE	LIG_APCC_ABBAyCdc20_2	0.2222
p.G103V	TCGA-DA-A1I1	SKCM	TCGA	KGKVFQE	LIG_APCC_ABBAyCdc20_2	0.6421
p.G103V	TCGA-FS-A1ZR	SKCM	TCGA	KGKVFQE	LIG_APCC_ABBAyCdc20_2	0.6421
p.G103V	DO37651	SKCM	ICGC	KGKVFQE	LIG_APCC_ABBAyCdc20_2	0.6421
p.G103V	DO37966	SKCM	ICGC	KGKVFQE	LIG_APCC_ABBAyCdc20_2	0.6421
p.E113A	TCGA-EB-A3Y6	SKCM	TCGA	KGKVFQE	LIG_APCC_ABBAyCdc20_2	0.1944
p.E113A	DO38081	SKCM	ICGC	KGKVFQE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R98C	DO233673	GACA	ICGC	KGKVFQE	LIG_APCC_ABBAyCdc20_2	0.2222
p.S117Y	SIDM00773	Non-Cancerous	GDSC	KGKVFQE	LIG_APCC_ABBAyCdc20_2	0.0833
p.S117Y	SIDM00774	Breast Carcinoma	GDSC	KGKVFQE	LIG_APCC_ABBAyCdc20_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07711	Procathepsin L	LIG_APCC_ABBAyCdc20_2	102:108	KGKVFQE	APC,CDC20,FZR1	0.9333	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons