DegronMD - P07911(UMOD)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A556G	TCGA-23-1022	OV	TCGA	VYLHCE	LIG_APCC_ABBA_1	562:567	Mutation rewiring degron network	0.1667
p.H565Q	TCGA-58-A46L	LUSC	TCGA	VYLHCE	LIG_APCC_ABBA_1	562:567	Mutation altering degron motif	0.7582
p.K577R	TCGA-CQ-5326	HNSC	TCGA	VYLHCE	LIG_APCC_ABBA_1	562:567	Mutation substituting flanking lysine	0.1667
p.R554W	TCGA-ER-A2NB	SKCM	TCGA	VYLHCE	LIG_APCC_ABBA_1	562:567	Mutation rewiring degron network	0.1111
p.C555Y	DO51899	BLCA	ICGC	VYLHCE	LIG_APCC_ABBA_1	562:567	Mutation rewiring degron network	0.1389
p.P559T	DO219037	BLCA	ICGC	VYLHCE	LIG_APCC_ABBA_1	562:567	Mutation rewiring degron network	0.25
p.K568T	DO227995	COCA	ICGC	VYLHCE	LIG_APCC_ABBA_1	562:567	Mutation rewiring degron network	0.3056
p.P577Q	DO233838	GACA	ICGC	VYLHCE	LIG_APCC_ABBA_1	562:567	Mutation substituting flanking lysine	0.1667
p.T564K	DO229045	LICA	ICGC	VYLHCE	LIG_APCC_ABBA_1	562:567	Mutation altering degron motif	0.7306
p.L567M	DO37445	SKCM	ICGC	VYLHCE	LIG_APCC_ABBA_1	562:567	Mutation altering degron motif	0.711
p.A557V	DO229250	THCA	ICGC	VYLHCE	LIG_APCC_ABBA_1	562:567	Mutation rewiring degron network	0.1944
p.N562H	DO41542	UCEC	ICGC	VYLHCE	LIG_APCC_ABBA_1	562:567	Mutation altering degron motif	0.7423
p.Q557H	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	VYLHCE	LIG_APCC_ABBA_1	562:567	Mutation rewiring degron network	0.1944
p.Q557H	NCI-H2126	lung	COSMIC	VYLHCE	LIG_APCC_ABBA_1	562:567	Mutation rewiring degron network	0.1944
p.H562Q	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	VYLHCE	LIG_APCC_ABBA_1	562:567	Mutation altering degron motif	0.7582
p.H562Q	CAL-12T	lung	COSMIC	VYLHCE	LIG_APCC_ABBA_1	562:567	Mutation altering degron motif	0.7582
p.E575K	SIDM00640	Mesothelioma	GDSC	VYLHCE	LIG_APCC_ABBA_1	562:567	Mutation rewiring degron network	0.1111
p.E575K	MSTO-211H	pleura	COSMIC	VYLHCE	LIG_APCC_ABBA_1	562:567	Mutation rewiring degron network	0.1111
p.V568I	ACH-000985	Colon/Colorectal Cancer	CCLE	VYLHCE	LIG_APCC_ABBA_1	562:567	Mutation rewiring degron network	0.3056
p.Q573H	NCI-H2126	lung	COSMIC	VYLHCE	LIG_APCC_ABBA_1	562:567	Mutation rewiring degron network	0.1667

Kaplan plot for UMOD in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UMOD

UniProt ID: P07911

Entrez ID: 7369

Protein name: Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UMOD in