DegronMD

Uniprot ID: P07911

Source protein: Uromodulin

Source gene: UMOD

Class: LIG_APCC_ABBA_1

Location: 562:567

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5954

ASA_SCORE: 25.25

COIL: 0.0292

CONS_SCORE: 0.8266

DSS_SCORE: 0.0113

HELIX: 0.003

FCONS_SCORE: 1.322

RIG_SCORE: 0.9933

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A556G	TCGA-23-1022	OV	TCGA	VYLHCE	LIG_APCC_ABBA_1	0.1667
p.H565Q	TCGA-58-A46L	LUSC	TCGA	VYLHCE	LIG_APCC_ABBA_1	0.7582
p.K577R	TCGA-CQ-5326	HNSC	TCGA	VYLHCE	LIG_APCC_ABBA_1	0.1667
p.R554W	TCGA-ER-A2NB	SKCM	TCGA	VYLHCE	LIG_APCC_ABBA_1	0.1111
p.C555Y	DO51899	BLCA	ICGC	VYLHCE	LIG_APCC_ABBA_1	0.1389
p.P559T	DO219037	BLCA	ICGC	VYLHCE	LIG_APCC_ABBA_1	0.25
p.K568T	DO227995	COCA	ICGC	VYLHCE	LIG_APCC_ABBA_1	0.3056
p.P577Q	DO233838	GACA	ICGC	VYLHCE	LIG_APCC_ABBA_1	0.1667
p.T564K	DO229045	LICA	ICGC	VYLHCE	LIG_APCC_ABBA_1	0.7306
p.L567M	DO37445	SKCM	ICGC	VYLHCE	LIG_APCC_ABBA_1	0.711
p.A557V	DO229250	THCA	ICGC	VYLHCE	LIG_APCC_ABBA_1	0.1944
p.N562H	DO41542	UCEC	ICGC	VYLHCE	LIG_APCC_ABBA_1	0.7423
p.Q557H	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	VYLHCE	LIG_APCC_ABBA_1	0.1944
p.Q557H	NCI-H2126	lung	COSMIC	VYLHCE	LIG_APCC_ABBA_1	0.1944
p.H562Q	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	VYLHCE	LIG_APCC_ABBA_1	0.7582
p.H562Q	CAL-12T	lung	COSMIC	VYLHCE	LIG_APCC_ABBA_1	0.7582
p.E575K	SIDM00640	Mesothelioma	GDSC	VYLHCE	LIG_APCC_ABBA_1	0.1111
p.E575K	MSTO-211H	pleura	COSMIC	VYLHCE	LIG_APCC_ABBA_1	0.1111
p.V568I	ACH-000985	Colon/Colorectal Cancer	CCLE	VYLHCE	LIG_APCC_ABBA_1	0.3056
p.Q573H	NCI-H2126	lung	COSMIC	VYLHCE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07911	Uromodulin	LIG_APCC_ABBA_1	562:567	VYLHCE	APC,CDC20,FZR1	0.5954	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons