DegronMD - P08123(COL1A2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1154V	TCGA-56-A49D	LUSC	TCGA	LLTPEGS	DEG_SCF_FBW7_1	1149:1155	Mutation altering degron motif	0.6421
p.G1154V	DO45475	LUSC	ICGC	LLTPEGS	DEG_SCF_FBW7_1	1149:1155	Mutation altering degron motif	0.6421
p.P1152H	TCGA-B5-A11E	UCEC	TCGA	LLTPEGS	DEG_SCF_FBW7_1	1149:1155	Mutation altering degron motif	0.7694
p.P1152H	DO41644	UCEC	ICGC	LLTPEGS	DEG_SCF_FBW7_1	1149:1155	Mutation altering degron motif	0.7694
p.S1155Y	TCGA-BR-8680	STAD	TCGA	LLTPEGS	DEG_SCF_FBW7_1	1149:1155	Mutation altering degron motif	0.8231
p.S1155Y	DO47769	STAD	ICGC	LLTPEGS	DEG_SCF_FBW7_1	1149:1155	Mutation altering degron motif	0.8231
p.T1162P	TCGA-CR-7374	HNSC	TCGA	LLTPEGS	DEG_SCF_FBW7_1	1149:1155	Mutation rewiring degron network	0.1389
p.T1162P	DO15334	HNSC	ICGC	LLTPEGS	DEG_SCF_FBW7_1	1149:1155	Mutation rewiring degron network	0.1389
p.N1143H	TCGA-CV-A6JZ	HNSC	TCGA	LLTPEGS	DEG_SCF_FBW7_1	1149:1155	Mutation rewiring degron network	0.1667
p.N1143H	DO52076	HNSC	ICGC	LLTPEGS	DEG_SCF_FBW7_1	1149:1155	Mutation rewiring degron network	0.1667
p.R1161H	TCGA-D1-A16D	UCEC	TCGA	LLTPEGS	DEG_SCF_FBW7_1	1149:1155	Mutation rewiring degron network	0.1667
p.R1161H	DO228398	PRAD	ICGC	LLTPEGS	DEG_SCF_FBW7_1	1149:1155	Mutation rewiring degron network	0.1667
p.R1161H	DO42217	UCEC	ICGC	LLTPEGS	DEG_SCF_FBW7_1	1149:1155	Mutation rewiring degron network	0.1667
p.L1150F	TCGA-D3-A8GL	SKCM	TCGA	LLTPEGS	DEG_SCF_FBW7_1	1149:1155	Mutation altering degron motif	0.587
p.L1150F	DO50287	SKCM	ICGC	LLTPEGS	DEG_SCF_FBW7_1	1149:1155	Mutation altering degron motif	0.587
p.P1159A	TCGA-DD-AADG	LIHC	TCGA	LLTPEGS	DEG_SCF_FBW7_1	1149:1155	Mutation rewiring degron network	0.2222
p.P1159A	DO219571	LIHC	ICGC	LLTPEGS	DEG_SCF_FBW7_1	1149:1155	Mutation rewiring degron network	0.2222
p.Q1145H	DO225215	BRCA	ICGC	LLTPEGS	DEG_SCF_FBW7_1	1149:1155	Mutation rewiring degron network	0.2222
p.Q1145H	DO227836	BRCA	ICGC	LLTPEGS	DEG_SCF_FBW7_1	1149:1155	Mutation rewiring degron network	0.2222
p.R1164H	DO233704	GACA	ICGC	LLTPEGS	DEG_SCF_FBW7_1	1149:1155	Mutation rewiring degron network	0.0833
p.P1152L	DO222632	MELA	ICGC	LLTPEGS	DEG_SCF_FBW7_1	1149:1155	Mutation altering degron motif	0.7582
p.R1161C	SIDM00193	Colorectal Carcinoma	GDSC	LLTPEGS	DEG_SCF_FBW7_1	1149:1155	Mutation rewiring degron network	0.1667
p.R1161C	ACH-000991	Colon/Colorectal Cancer	CCLE	LLTPEGS	DEG_SCF_FBW7_1	1149:1155	Mutation rewiring degron network	0.1667
p.R1161C	SNU-81	large intestine	COSMIC	LLTPEGS	DEG_SCF_FBW7_1	1149:1155	Mutation rewiring degron network	0.1667
p.R1159C	SNU-81	large intestine	COSMIC	LLTPEGS	DEG_SCF_FBW7_1	1149:1155	Mutation rewiring degron network	0.2222

Kaplan plot for COL1A2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL1A2

UniProt ID: P08123

Entrez ID: 1278

Protein name: Collagen alpha-2(I) chain (Alpha-2 type I collagen)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COL1A2 in