DegronMD

Uniprot ID: P08123

Source protein: Collagen alpha-2

Source gene: COL1A2

Class: DEG_SCF_FBW7_1

Location: 1149:1155

E3 ligase: FBXW7

DEGRON score: 0.9985

ASA_SCORE: 49.4286

COIL: 0.7449

CONS_SCORE: 0.7546

DSS_SCORE: 0.5336

HELIX: 0.195

FCONS_SCORE: 1.0138

RIG_SCORE: 0.7255

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1154V	TCGA-56-A49D	LUSC	TCGA	LLTPEGS	DEG_SCF_FBW7_1	0.6421
p.G1154V	DO45475	LUSC	ICGC	LLTPEGS	DEG_SCF_FBW7_1	0.6421
p.P1152H	TCGA-B5-A11E	UCEC	TCGA	LLTPEGS	DEG_SCF_FBW7_1	0.7694
p.P1152H	DO41644	UCEC	ICGC	LLTPEGS	DEG_SCF_FBW7_1	0.7694
p.S1155Y	TCGA-BR-8680	STAD	TCGA	LLTPEGS	DEG_SCF_FBW7_1	0.8231
p.S1155Y	DO47769	STAD	ICGC	LLTPEGS	DEG_SCF_FBW7_1	0.8231
p.T1162P	TCGA-CR-7374	HNSC	TCGA	LLTPEGS	DEG_SCF_FBW7_1	0.1389
p.T1162P	DO15334	HNSC	ICGC	LLTPEGS	DEG_SCF_FBW7_1	0.1389
p.N1143H	TCGA-CV-A6JZ	HNSC	TCGA	LLTPEGS	DEG_SCF_FBW7_1	0.1667
p.N1143H	DO52076	HNSC	ICGC	LLTPEGS	DEG_SCF_FBW7_1	0.1667
p.R1161H	TCGA-D1-A16D	UCEC	TCGA	LLTPEGS	DEG_SCF_FBW7_1	0.1667
p.R1161H	DO228398	PRAD	ICGC	LLTPEGS	DEG_SCF_FBW7_1	0.1667
p.R1161H	DO42217	UCEC	ICGC	LLTPEGS	DEG_SCF_FBW7_1	0.1667
p.L1150F	TCGA-D3-A8GL	SKCM	TCGA	LLTPEGS	DEG_SCF_FBW7_1	0.587
p.L1150F	DO50287	SKCM	ICGC	LLTPEGS	DEG_SCF_FBW7_1	0.587
p.P1159A	TCGA-DD-AADG	LIHC	TCGA	LLTPEGS	DEG_SCF_FBW7_1	0.2222
p.P1159A	DO219571	LIHC	ICGC	LLTPEGS	DEG_SCF_FBW7_1	0.2222
p.Q1145H	DO225215	BRCA	ICGC	LLTPEGS	DEG_SCF_FBW7_1	0.2222
p.Q1145H	DO227836	BRCA	ICGC	LLTPEGS	DEG_SCF_FBW7_1	0.2222
p.R1164H	DO233704	GACA	ICGC	LLTPEGS	DEG_SCF_FBW7_1	0.0833
p.P1152L	DO222632	MELA	ICGC	LLTPEGS	DEG_SCF_FBW7_1	0.7582
p.R1161C	SIDM00193	Colorectal Carcinoma	GDSC	LLTPEGS	DEG_SCF_FBW7_1	0.1667
p.R1161C	ACH-000991	Colon/Colorectal Cancer	CCLE	LLTPEGS	DEG_SCF_FBW7_1	0.1667
p.R1161C	SNU-81	large_intestine	COSMIC	LLTPEGS	DEG_SCF_FBW7_1	0.1667
p.R1159C	SNU-81	large_intestine	COSMIC	LLTPEGS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08123	Collagen alpha-2	DEG_SCF_FBW7_1	1149:1155	LLTPEGS	FBXW7	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons