CD55
UniProt ID: P08174
Entrez ID: 1604
Protein name: Complement decay-accelerating factor (CD antigen CD55)
External links: UniprotKB HGNC RefSeq COSMIC
Please click HERE
for better display.
FUNCTION: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the ...
FUNCTION: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829). {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:28657829}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. {ECO:0000269|PubMed:9151867}.; FUNCTION: (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). {ECO:0000269|PubMed:8764022}.; FUNCTION: (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:12409401}.
View more >>
GO - Biological processes (BP):
complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; negative regulation of complement activation [GO:0045916]; negative regulation of complement activation, classical pathway [GO:0045959]; positive regulation of CD4-positive, alpha-beta T cell activation [GO:2...
complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; negative regulation of complement activation [GO:0045916]; negative regulation of complement activation, classical pathway [GO:0045959]; positive regulation of CD4-positive, alpha-beta T cell activation [GO:2000516]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of T cell cytokine production [GO:0002726]; regulation of complement activation [GO:0030449]; regulation of complement-dependent cytotoxicity [GO:1903659]; regulation of lipopolysaccharide-mediated signaling pathway [GO:0031664]; respiratory burst [GO:0045730]; T cell mediated immunity [GO:0002456]
View more >>
GO - Molecular function (MF):
lipid binding [GO:0008289]; virus receptor activity [GO:0001618]...
lipid binding [GO:0008289]; virus receptor activity [GO:0001618]
View more >>
GO - Cellular component (CC):
anchored component of membrane [GO:0031225]; cell surface [GO:0009986]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule membrane [GO:0101003]; Golgi membrane [GO:0000139]; membra...
anchored component of membrane [GO:0031225]; cell surface [GO:0009986]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule membrane [GO:0101003]; Golgi membrane [GO:0000139]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; transport vesicle [GO:0030133]
View more >>
CD55
Control panel
Show dataset:
Show Degron:
All sites
Degron
Degron
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for CD55 in
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc