DegronMD

Uniprot ID: P08174

Source protein: Complement decay-accelerating factor

Source gene: CD55

Class: DEG_SCF_SKP2-CKS1_1

Location: 340:347

E3 ligase: SKP2,CSK1

DEGRON score: 0.822

ASA_SCORE: 101.1625

COIL: 0.8853

CONS_SCORE: 0.4308

DSS_SCORE: 0.6979

HELIX: 0.026

FCONS_SCORE: 0.8369

RIG_SCORE: 0.6682

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H341N	TCGA-66-2789	LUSC	TCGA	FHETTPNK	DEG_SCF_SKP2-CKS1_1	0.6312
p.H341N	DO27279	LUSC	ICGC	FHETTPNK	DEG_SCF_SKP2-CKS1_1	0.6312
p.T331I	TCGA-AA-3713	COAD	TCGA	FHETTPNK	DEG_SCF_SKP2-CKS1_1	0.0833
p.T331I	DO8400	COAD	ICGC	FHETTPNK	DEG_SCF_SKP2-CKS1_1	0.0833
p.S334F	TCGA-EE-A2MR	SKCM	TCGA	FHETTPNK	DEG_SCF_SKP2-CKS1_1	0.6111
p.S334F	TCGA-GF-A6C9	SKCM	TCGA	FHETTPNK	DEG_SCF_SKP2-CKS1_1	0.6111
p.S334F	DO37819	SKCM	ICGC	FHETTPNK	DEG_SCF_SKP2-CKS1_1	0.6111
p.S334F	DO51254	SKCM	ICGC	FHETTPNK	DEG_SCF_SKP2-CKS1_1	0.6111
p.H341Y	DO1243	BRCA	ICGC	FHETTPNK	DEG_SCF_SKP2-CKS1_1	0.6118
p.H341Y	DO222632	MELA	ICGC	FHETTPNK	DEG_SCF_SKP2-CKS1_1	0.6118
p.K338N	SIDM00216	Colorectal Carcinoma	GDSC	FHETTPNK	DEG_SCF_SKP2-CKS1_1	0.7222
p.K338N	SNU-175	large_intestine	COSMIC	FHETTPNK	DEG_SCF_SKP2-CKS1_1	0.7222
p.T336I	SIDM00608	Plasma Cell Myeloma	GDSC	FHETTPNK	DEG_SCF_SKP2-CKS1_1	0.2222
p.T336I	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	FHETTPNK	DEG_SCF_SKP2-CKS1_1	0.2222
p.T344I	SIDM00967	Ovarian Carcinoma	GDSC	FHETTPNK	DEG_SCF_SKP2-CKS1_1	0.7078
p.K347E	SIDM00379	Glioma	GDSC	FHETTPNK	DEG_SCF_SKP2-CKS1_1	0.7022
p.V333I	SIDM00808	Burkitt's Lymphoma	GDSC	FHETTPNK	DEG_SCF_SKP2-CKS1_1	0.1389
p.V333I	SIDM01254	Burkitt's Lymphoma	GDSC	FHETTPNK	DEG_SCF_SKP2-CKS1_1	0.1389
p.S343L	T98G	central_nervous_system	COSMIC	FHETTPNK	DEG_SCF_SKP2-CKS1_1	0.7667
p.P351S	MCC13	skin	COSMIC	FHETTPNK	DEG_SCF_SKP2-CKS1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08174	Complement decay-accelerating factor	DEG_SCF_SKP2-CKS1_1	340:347	FHETTPNK	SKP2,CSK1	0.822	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons