DegronMD - P08195(SLC3A2)

FUNCTION: Component of several heterodimeric complexes involved in amino acid transport (PubMed:11557028, PubMed:9829974, PubMed:9751058, PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:30341327). The precise substrate specificity depends on the other subunit in the heterodimer (PubMed:9829974, PubMed:9751058, PubMed:10391915, PubMed:10574970, PubMed:30867591, PubMed:10903140). The complexes function as amino acid exchangers (PubMed:11557028, PubMed:10903140, PubMed:12117417, PubMed:12225859, PubMed:30867591). The homodimer functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan (PubMed:9751058, PubMed:11557028, PubMed:11311135, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:25998567, PubMed:30867591). The heterodimer formed by SLC3A2 and SLC7A6 or SLC3A2 and SLC7A7 mediates the uptake of dibasic amino acids (PubMed:9829974, PubMed:10903140). The heterodimer with SLC7A5/LAT1 mediates the transport of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane (PubMed:11564694, PubMed:12225859). The heterodimer with SLC7A5/LAT1 is involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes (PubMed:12117417). The heterodimer with SLC7A5/LAT1 is involved in the uptake of leucine (PubMed:25998567, PubMed:30341327). When associated with LAPTM4B, the heterodimer with SLC7A5/LAT1 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). The heterodimer with SLC7A5/LAT1 may play a role in the transport of L-DOPA across the blood-brain barrier (By similarity). The heterodimer formed by SLC3A2 and SLC7A5/LAT1 or SLC3A2 and SLC7A8/LAT2 is involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane (PubMed:15769744). Together with ICAM1, regulates the transport activity of SLC7A8/LAT2 in polarized intestinal cells by generating and delivering intracellular signals (PubMed:12716892). Required for targeting of SLC7A5/LAT1 and SLC7A8/LAT2 to the plasma membrane and for channel activity (PubMed:9751058, PubMed:11311135, PubMed:30867591). Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine (PubMed:14603368). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity). {ECO:0000250|UniProtKB:P10852, ECO:0000250|UniProtKB:Q794F9, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30341327, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269|PubMed:30341327}. View more >>

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R535H	TCGA-A5-A0G1	UCEC	TCGA	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation altering degron motif	0.8244
p.R535H	DO232761	PBCA	ICGC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation altering degron motif	0.8244
p.R535H	DO42472	UCEC	ICGC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation altering degron motif	0.8244
p.R535H	SIDM00789	Colorectal Carcinoma	GDSC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation altering degron motif	0.8244
p.R535H	HCT-15	large intestine	COSMIC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation altering degron motif	0.8244
p.R535C	TCGA-CM-4743	COAD	TCGA	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation altering degron motif	0.8301
p.R531Q	TCGA-DU-6392	LGG	TCGA	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation blocking phosphorylation signal	0.6944
p.R525W	TCGA-G4-6586	COAD	TCGA	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation rewiring degron network	0.0833
p.L527P	TCGA-ZH-A8Y1	CHOL	TCGA	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation blocking phosphorylation signal	0.5833
p.S544L	DO219066	BLCA	ICGC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation rewiring degron network	0.2222
p.S544L	DO37406	SKCM	ICGC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation rewiring degron network	0.2222
p.R524H	DO9002	COAD	ICGC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation rewiring degron network	0.0556
p.R524H	HCT-116	large intestine	COSMIC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation rewiring degron network	0.0556
p.R535L	DO229036	LICA	ICGC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation altering degron motif	0.8428
p.S536F	DO220891	MELA	ICGC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation altering degron motif	0.7982
p.Q530L	SIDM00524	Small Cell Lung Carcinoma	GDSC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation rewiring degron network	0.2222
p.Q530L	DMS-79	lung	COSMIC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation rewiring degron network	0.2222
p.F545L	SIDM01007	T-Lymphoblastic Leukemia	GDSC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation rewiring degron network	0.1944
p.F545L	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation rewiring degron network	0.1944
p.A544V	SIDM00210	Ovarian Carcinoma	GDSC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation rewiring degron network	0.2222
p.A544V	SIDM01147	Gastric Carcinoma	GDSC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation rewiring degron network	0.2222
p.A544E	SIDM00165	Other Solid Cancers	GDSC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation rewiring degron network	0.2222
p.A525T	ACH-000956	Prostate Cancer	CCLE	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation rewiring degron network	0.0833
p.A525T	22RV1	prostate	COSMIC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation rewiring degron network	0.0833
p.R541C	ACH-000974	Endometrial/Uterine Cancer	CCLE	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation rewiring degron network	0.3056
p.R541C	ACH-002026	Endometrial/Uterine Cancer	CCLE	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation rewiring degron network	0.3056
p.R541C	SNG-M	endometrium	COSMIC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation rewiring degron network	0.3056
p.E550G	ACH-000999	Colon/Colorectal Cancer	CCLE	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation rewiring degron network	0.0556
p.E550G	SNU-1040	large intestine	COSMIC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation rewiring degron network	0.0556
p.D527E	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation blocking phosphorylation signal	0.5833
p.F544L	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation rewiring degron network	0.2222
p.R534H	HCT-15	large intestine	COSMIC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation altering degron motif	0.8244
p.Q529L	DMS-79	lung	COSMIC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	534:540	Mutation rewiring degron network	0.1944

Kaplan plot for SLC3A2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC3A2

UniProt ID: P08195

Entrez ID: 6520

Protein name: 4F2 cell-surface antigen heavy chain (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC3A2 in