DegronMD

Uniprot ID: P08195

Source protein: 4F2 cell-surface antigen heavy chain

Source gene: SLC3A2

Class: LIG_APCC_ABBAyCdc20_2

Location: 534:540

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6988

ASA_SCORE: 64.0857

COIL: 0.4767

CONS_SCORE: 0.38

DSS_SCORE: 0.3056

HELIX: 0.1146

FCONS_SCORE: 1.0728

RIG_SCORE: 0.7114

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R535H	TCGA-A5-A0G1	UCEC	TCGA	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.8244
p.R535H	DO232761	PBCA	ICGC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.8244
p.R535H	DO42472	UCEC	ICGC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.8244
p.R535H	SIDM00789	Colorectal Carcinoma	GDSC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.8244
p.R535H	HCT-15	large_intestine	COSMIC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.8244
p.R535C	TCGA-CM-4743	COAD	TCGA	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.8301
p.R531Q	TCGA-DU-6392	LGG	TCGA	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.6944
p.R525W	TCGA-G4-6586	COAD	TCGA	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.0833
p.L527P	TCGA-ZH-A8Y1	CHOL	TCGA	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.5833
p.S544L	DO219066	BLCA	ICGC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.S544L	DO37406	SKCM	ICGC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R524H	DO9002	COAD	ICGC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R524H	HCT-116	large_intestine	COSMIC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R535L	DO229036	LICA	ICGC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.8428
p.S536F	DO220891	MELA	ICGC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.7982
p.Q530L	SIDM00524	Small Cell Lung Carcinoma	GDSC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.Q530L	DMS-79	lung	COSMIC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.F545L	SIDM01007	T-Lymphoblastic Leukemia	GDSC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.F545L	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.A544V	SIDM00210	Ovarian Carcinoma	GDSC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.A544V	SIDM01147	Gastric Carcinoma	GDSC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.A544E	SIDM00165	Other Solid Cancers	GDSC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.A525T	ACH-000956	Prostate Cancer	CCLE	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.0833
p.A525T	22RV1	prostate	COSMIC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R541C	ACH-000974	Endometrial/Uterine Cancer	CCLE	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R541C	ACH-002026	Endometrial/Uterine Cancer	CCLE	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R541C	SNG-M	endometrium	COSMIC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E550G	ACH-000999	Colon/Colorectal Cancer	CCLE	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.0556
p.E550G	SNU-1040	large_intestine	COSMIC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.0556
p.D527E	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.5833
p.F544L	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R534H	HCT-15	large_intestine	COSMIC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.8244
p.Q529L	DMS-79	lung	COSMIC	RSLLHGD	LIG_APCC_ABBAyCdc20_2	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RSLLHGD

Degron related mutations and impact score

Drug responses associated with SLC3A2 mutations

All proteins holding degron of RSLLHGD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08195	4F2 cell-surface antigen heavy chain	LIG_APCC_ABBAyCdc20_2	534:540	RSLLHGD	APC,CDC20,FZR1	0.6988	More...