DegronMD - P08237(PFKM)

PFKM

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K749T	TCGA-17-Z031	LUAD	TCGA	LRPILKILA	DEG_APCC_DBOX_1	745:753	Mutation altering degron motif	0.7306
p.Q735L	TCGA-34-5231	LUSC	TCGA	LRPILKILA	DEG_APCC_DBOX_1	745:753	Mutation rewiring degron network	0.0556
p.W757C	TCGA-AA-3854	COAD	TCGA	LRPILKILA	DEG_APCC_DBOX_1	745:753	Mutation rewiring degron network	0.2222
p.R744M	TCGA-AP-A059	UCEC	TCGA	LRPILKILA	DEG_APCC_DBOX_1	745:753	Mutation rewiring degron network	0.3056
p.G736C	TCGA-CN-6010	HNSC	TCGA	LRPILKILA	DEG_APCC_DBOX_1	745:753	Mutation rewiring degron network	0.0833
p.A752T	TCGA-IB-7651	PAAD	TCGA	LRPILKILA	DEG_APCC_DBOX_1	745:753	Mutation altering degron motif	0.7139
p.A752T	SNU-C1	large intestine	COSMIC	LRPILKILA	DEG_APCC_DBOX_1	745:753	Mutation altering degron motif	0.7139
p.A752T	SNU-175	large intestine	COSMIC	LRPILKILA	DEG_APCC_DBOX_1	745:753	Mutation altering degron motif	0.7139
p.A748T	DO21821	LAML	ICGC	LRPILKILA	DEG_APCC_DBOX_1	745:753	Mutation altering degron motif	0.7139
p.G745R	DO34024	PACA	ICGC	LRPILKILA	DEG_APCC_DBOX_1	745:753	Mutation altering degron motif	0.7568
p.R741W	DO43626	UCEC	ICGC	LRPILKILA	DEG_APCC_DBOX_1	745:753	Mutation rewiring degron network	0.2222
p.R735Q	ACH-001081	Colon/Colorectal Cancer	CCLE	LRPILKILA	DEG_APCC_DBOX_1	745:753	Mutation rewiring degron network	0.0556
p.R735Q	HCC2998	large intestine	COSMIC	LRPILKILA	DEG_APCC_DBOX_1	745:753	Mutation rewiring degron network	0.0556
p.M755I	NCI-H650	lung	COSMIC	LRPILKILA	DEG_APCC_DBOX_1	745:753	Mutation blocking phosphorylation signal	0.7222

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*NOTE: the Kaplan plots were collected from OncoLnc