DegronMD

Uniprot ID: P08237

Source protein: ATP-dependent 6-phosphofructokinase, muscle type

Source gene: PFKM

Class: DEG_APCC_DBOX_1

Location: 745:753

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5628

ASA_SCORE: 34.9778

COIL: 0.1196

CONS_SCORE: 0.2812

DSS_SCORE: 0.0284

HELIX: 0.8707

FCONS_SCORE: 1.039

RIG_SCORE: 0.9229

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K749T	TCGA-17-Z031	LUAD	TCGA	LRPILKILA	DEG_APCC_DBOX_1	0.7306
p.Q735L	TCGA-34-5231	LUSC	TCGA	LRPILKILA	DEG_APCC_DBOX_1	0.0556
p.W757C	TCGA-AA-3854	COAD	TCGA	LRPILKILA	DEG_APCC_DBOX_1	0.2222
p.R744M	TCGA-AP-A059	UCEC	TCGA	LRPILKILA	DEG_APCC_DBOX_1	0.3056
p.G736C	TCGA-CN-6010	HNSC	TCGA	LRPILKILA	DEG_APCC_DBOX_1	0.0833
p.A752T	TCGA-IB-7651	PAAD	TCGA	LRPILKILA	DEG_APCC_DBOX_1	0.7139
p.A752T	SNU-C1	large_intestine	COSMIC	LRPILKILA	DEG_APCC_DBOX_1	0.7139
p.A752T	SNU-175	large_intestine	COSMIC	LRPILKILA	DEG_APCC_DBOX_1	0.7139
p.A748T	DO21821	LAML	ICGC	LRPILKILA	DEG_APCC_DBOX_1	0.7139
p.G745R	DO34024	PACA	ICGC	LRPILKILA	DEG_APCC_DBOX_1	0.7568
p.R741W	DO43626	UCEC	ICGC	LRPILKILA	DEG_APCC_DBOX_1	0.2222
p.R735Q	ACH-001081	Colon/Colorectal Cancer	CCLE	LRPILKILA	DEG_APCC_DBOX_1	0.0556
p.R735Q	HCC2998	large_intestine	COSMIC	LRPILKILA	DEG_APCC_DBOX_1	0.0556
p.M755I	NCI-H650	lung	COSMIC	LRPILKILA	DEG_APCC_DBOX_1	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08237	ATP-dependent 6-phosphofructokinase, muscle type	DEG_APCC_DBOX_1	745:753	LRPILKILA	APC,CDC20,FZR1	0.5628	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons