DegronMD - P08572(COL4A2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1069W	TCGA-55-7995	LUAD	TCGA	RAGLYGE	LIG_APCC_ABBAyCdc20_2	1077:1083	Mutation rewiring degron network	0.1111
p.R1069W	DO45323	LUAD	ICGC	RAGLYGE	LIG_APCC_ABBAyCdc20_2	1077:1083	Mutation rewiring degron network	0.1111
p.I1093T	TCGA-B5-A3FC	UCEC	TCGA	RAGLYGE	LIG_APCC_ABBAyCdc20_2	1077:1083	Mutation rewiring degron network	0.0556
p.I1093T	DO41871	UCEC	ICGC	RAGLYGE	LIG_APCC_ABBAyCdc20_2	1077:1083	Mutation rewiring degron network	0.0556
p.G1076R	TCGA-ED-A7XP	LIHC	TCGA	RAGLYGE	LIG_APCC_ABBAyCdc20_2	1077:1083	Mutation rewiring degron network	0.3056
p.G1076R	DO48562	LIHC	ICGC	RAGLYGE	LIG_APCC_ABBAyCdc20_2	1077:1083	Mutation rewiring degron network	0.3056
p.E1083K	TCGA-FR-A3YO	SKCM	TCGA	RAGLYGE	LIG_APCC_ABBAyCdc20_2	1077:1083	Mutation altering degron motif	0.7022
p.E1083K	DO37419	SKCM	ICGC	RAGLYGE	LIG_APCC_ABBAyCdc20_2	1077:1083	Mutation altering degron motif	0.7022
p.R1069L	TCGA-FS-A1ZB	SKCM	TCGA	RAGLYGE	LIG_APCC_ABBAyCdc20_2	1077:1083	Mutation rewiring degron network	0.1111
p.R1069L	DO37886	SKCM	ICGC	RAGLYGE	LIG_APCC_ABBAyCdc20_2	1077:1083	Mutation rewiring degron network	0.1111
p.D1071G	SIDM00600	Thyroid Gland Carcinoma	GDSC	RAGLYGE	LIG_APCC_ABBAyCdc20_2	1077:1083	Mutation rewiring degron network	0.1667
p.D1071G	ACH-000467	Colon/Colorectal Cancer	CCLE	RAGLYGE	LIG_APCC_ABBAyCdc20_2	1077:1083	Mutation rewiring degron network	0.1667
p.D1071G	ACH-001528	Thyroid Cancer	CCLE	RAGLYGE	LIG_APCC_ABBAyCdc20_2	1077:1083	Mutation rewiring degron network	0.1667
p.D1071G	HCC-56	large intestine	COSMIC	RAGLYGE	LIG_APCC_ABBAyCdc20_2	1077:1083	Mutation rewiring degron network	0.1667
p.D1071G	IHH-4	thyroid	COSMIC	RAGLYGE	LIG_APCC_ABBAyCdc20_2	1077:1083	Mutation rewiring degron network	0.1667
p.A1086V	SIDM00842	Colorectal Carcinoma	GDSC	RAGLYGE	LIG_APCC_ABBAyCdc20_2	1077:1083	Mutation rewiring degron network	0.25
p.G1091D	SIDM00240	Cervical Carcinoma	GDSC	RAGLYGE	LIG_APCC_ABBAyCdc20_2	1077:1083	Mutation rewiring degron network	0.1111
p.G1091D	OMC-1	cervix	COSMIC	RAGLYGE	LIG_APCC_ABBAyCdc20_2	1077:1083	Mutation rewiring degron network	0.1111

Kaplan plot for COL4A2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL4A2

UniProt ID: P08572

Entrez ID: 1284

Protein name: Collagen alpha-2(IV) chain [Cleaved into: Canstatin]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COL4A2 in