DegronMD

Uniprot ID: P08572

Source protein: Collagen alpha-2

Source gene: COL4A2

Class: LIG_APCC_ABBAyCdc20_2

Location: 1077:1083

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9915

ASA_SCORE: 77.8286

COIL: 0.8404

CONS_SCORE: 0.4739

DSS_SCORE: 0.4491

HELIX: 0.0254

FCONS_SCORE: 1.1494

RIG_SCORE: 0.7288

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1069W	TCGA-55-7995	LUAD	TCGA	RAGLYGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R1069W	DO45323	LUAD	ICGC	RAGLYGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.I1093T	TCGA-B5-A3FC	UCEC	TCGA	RAGLYGE	LIG_APCC_ABBAyCdc20_2	0.0556
p.I1093T	DO41871	UCEC	ICGC	RAGLYGE	LIG_APCC_ABBAyCdc20_2	0.0556
p.G1076R	TCGA-ED-A7XP	LIHC	TCGA	RAGLYGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.G1076R	DO48562	LIHC	ICGC	RAGLYGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.E1083K	TCGA-FR-A3YO	SKCM	TCGA	RAGLYGE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E1083K	DO37419	SKCM	ICGC	RAGLYGE	LIG_APCC_ABBAyCdc20_2	0.7022
p.R1069L	TCGA-FS-A1ZB	SKCM	TCGA	RAGLYGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R1069L	DO37886	SKCM	ICGC	RAGLYGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.D1071G	SIDM00600	Thyroid Gland Carcinoma	GDSC	RAGLYGE	LIG_APCC_ABBAyCdc20_2	0.1667
p.D1071G	ACH-000467	Colon/Colorectal Cancer	CCLE	RAGLYGE	LIG_APCC_ABBAyCdc20_2	0.1667
p.D1071G	ACH-001528	Thyroid Cancer	CCLE	RAGLYGE	LIG_APCC_ABBAyCdc20_2	0.1667
p.D1071G	HCC-56	large_intestine	COSMIC	RAGLYGE	LIG_APCC_ABBAyCdc20_2	0.1667
p.D1071G	IHH-4	thyroid	COSMIC	RAGLYGE	LIG_APCC_ABBAyCdc20_2	0.1667
p.A1086V	SIDM00842	Colorectal Carcinoma	GDSC	RAGLYGE	LIG_APCC_ABBAyCdc20_2	0.25
p.G1091D	SIDM00240	Cervical Carcinoma	GDSC	RAGLYGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.G1091D	OMC-1	cervix	COSMIC	RAGLYGE	LIG_APCC_ABBAyCdc20_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08572	Collagen alpha-2	LIG_APCC_ABBAyCdc20_2	1077:1083	RAGLYGE	APC,CDC20,FZR1	0.9915	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons