DegronMD - P08603(CFH)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K224N	TCGA-33-AASB	LUSC	TCGA	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation substituting flanking lysine	0.3611
p.K224N	DO219125	LUSC	ICGC	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation substituting flanking lysine	0.3611
p.I225S	TCGA-AG-A002	READ	TCGA	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.2778
p.R232Q	TCGA-AP-A1E0	UCEC	TCGA	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.3056
p.R232Q	TCGA-AX-A0J0	UCEC	TCGA	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.3056
p.R232Q	DO220907	MELA	ICGC	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.3056
p.R232Q	DO222572	MELA	ICGC	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.3056
p.R232Q	DO43154	UCEC	ICGC	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.3056
p.R232Q	DO41133	UCEC	ICGC	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.3056
p.S222F	TCGA-B5-A1MR	UCEC	TCGA	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.1944
p.S222F	DO41758	UCEC	ICGC	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.1944
p.C237R	TCGA-B5-A1MX	UCEC	TCGA	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.1667
p.C237R	DO41999	UCEC	ICGC	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.1667
p.I221M	TCGA-DD-AAEA	LIHC	TCGA	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.1667
p.I221M	DO52266	LIHC	ICGC	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.1667
p.S219Y	TCGA-E6-A1LX	UCEC	TCGA	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.1111
p.S219Y	DO229275	THCA	ICGC	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.1111
p.S219Y	DO41020	UCEC	ICGC	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.1111
p.P220S	TCGA-EE-A29S	SKCM	TCGA	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.1389
p.P220S	DO37936	SKCM	ICGC	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.1389
p.E229K	TCGA-EE-A2MJ	SKCM	TCGA	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation altering degron motif	0.7022
p.E229K	DO38099	SKCM	ICGC	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation altering degron motif	0.7022
p.E229A	DO804	BLCA	ICGC	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation altering degron motif	0.7701
p.E229A	DO234437	ESAD	ICGC	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation altering degron motif	0.7701
p.K228T	DO234333	ESAD	ICGC	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation altering degron motif	0.7306
p.G218V	DO229036	LICA	ICGC	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.0833
p.I221V	DO23549	LIRI	ICGC	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.1667
p.Q223H	SIDM01954	Colorectal Carcinoma	GDSC	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.2222
p.Y227C	SIDM00252	Biliary Tract Carcinoma	GDSC	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation altering degron motif	0.5976
p.Y227C	TGBC1TKB	biliary tract	COSMIC	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation altering degron motif	0.5976
p.I226V	SIDM01611	Endometrial Carcinoma	GDSC	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.3056
p.R221K	ACH-000848	Liver Cancer	CCLE	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.1667
p.R221K	JHH-7	liver	COSMIC	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.1667
p.H220Y	ACH-000849	Breast Cancer	CCLE	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.1389
p.H220Y	MDA-MB-468	breast	COSMIC	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.1389
p.T227S	ACH-000963	Colon/Colorectal Cancer	CCLE	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation altering degron motif	0.7116
p.T227S	CCK-81	large intestine	COSMIC	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation altering degron motif	0.7116
p.P236S	ACH-000990	Endometrial/Uterine Cancer	CCLE	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation substituting flanking lysine	0.3056
p.R221I	ACH-001559	Lung Cancer	CCLE	YKENE	DEG_APCC_KENBOX_2	227:231	Mutation rewiring degron network	0.1667

Kaplan plot for CFH in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CFH

UniProt ID: P08603

Entrez ID: 3075

Protein name: Complement factor H (H factor 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CFH in