DegronMD

Uniprot ID: P08603

Source protein: Complement factor H

Source gene: CFH

Class: DEG_APCC_KENBOX_2

Location: 227:231

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9093

ASA_SCORE: 71.2

COIL: 0.8994

CONS_SCORE: 0.4262

DSS_SCORE: 0.2175

HELIX: 0.0042

FCONS_SCORE: 0.7989

RIG_SCORE: 0.8758

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K224N	TCGA-33-AASB	LUSC	TCGA	YKENE	DEG_APCC_KENBOX_2	0.3611
p.K224N	DO219125	LUSC	ICGC	YKENE	DEG_APCC_KENBOX_2	0.3611
p.I225S	TCGA-AG-A002	READ	TCGA	YKENE	DEG_APCC_KENBOX_2	0.2778
p.R232Q	TCGA-AP-A1E0	UCEC	TCGA	YKENE	DEG_APCC_KENBOX_2	0.3056
p.R232Q	TCGA-AX-A0J0	UCEC	TCGA	YKENE	DEG_APCC_KENBOX_2	0.3056
p.R232Q	DO220907	MELA	ICGC	YKENE	DEG_APCC_KENBOX_2	0.3056
p.R232Q	DO222572	MELA	ICGC	YKENE	DEG_APCC_KENBOX_2	0.3056
p.R232Q	DO43154	UCEC	ICGC	YKENE	DEG_APCC_KENBOX_2	0.3056
p.R232Q	DO41133	UCEC	ICGC	YKENE	DEG_APCC_KENBOX_2	0.3056
p.S222F	TCGA-B5-A1MR	UCEC	TCGA	YKENE	DEG_APCC_KENBOX_2	0.1944
p.S222F	DO41758	UCEC	ICGC	YKENE	DEG_APCC_KENBOX_2	0.1944
p.C237R	TCGA-B5-A1MX	UCEC	TCGA	YKENE	DEG_APCC_KENBOX_2	0.1667
p.C237R	DO41999	UCEC	ICGC	YKENE	DEG_APCC_KENBOX_2	0.1667
p.I221M	TCGA-DD-AAEA	LIHC	TCGA	YKENE	DEG_APCC_KENBOX_2	0.1667
p.I221M	DO52266	LIHC	ICGC	YKENE	DEG_APCC_KENBOX_2	0.1667
p.S219Y	TCGA-E6-A1LX	UCEC	TCGA	YKENE	DEG_APCC_KENBOX_2	0.1111
p.S219Y	DO229275	THCA	ICGC	YKENE	DEG_APCC_KENBOX_2	0.1111
p.S219Y	DO41020	UCEC	ICGC	YKENE	DEG_APCC_KENBOX_2	0.1111
p.P220S	TCGA-EE-A29S	SKCM	TCGA	YKENE	DEG_APCC_KENBOX_2	0.1389
p.P220S	DO37936	SKCM	ICGC	YKENE	DEG_APCC_KENBOX_2	0.1389
p.E229K	TCGA-EE-A2MJ	SKCM	TCGA	YKENE	DEG_APCC_KENBOX_2	0.7022
p.E229K	DO38099	SKCM	ICGC	YKENE	DEG_APCC_KENBOX_2	0.7022
p.E229A	DO804	BLCA	ICGC	YKENE	DEG_APCC_KENBOX_2	0.7701
p.E229A	DO234437	ESAD	ICGC	YKENE	DEG_APCC_KENBOX_2	0.7701
p.K228T	DO234333	ESAD	ICGC	YKENE	DEG_APCC_KENBOX_2	0.7306
p.G218V	DO229036	LICA	ICGC	YKENE	DEG_APCC_KENBOX_2	0.0833
p.I221V	DO23549	LIRI	ICGC	YKENE	DEG_APCC_KENBOX_2	0.1667
p.Q223H	SIDM01954	Colorectal Carcinoma	GDSC	YKENE	DEG_APCC_KENBOX_2	0.2222
p.Y227C	SIDM00252	Biliary Tract Carcinoma	GDSC	YKENE	DEG_APCC_KENBOX_2	0.5976
p.Y227C	TGBC1TKB	biliary_tract	COSMIC	YKENE	DEG_APCC_KENBOX_2	0.5976
p.I226V	SIDM01611	Endometrial Carcinoma	GDSC	YKENE	DEG_APCC_KENBOX_2	0.3056
p.R221K	ACH-000848	Liver Cancer	CCLE	YKENE	DEG_APCC_KENBOX_2	0.1667
p.R221K	JHH-7	liver	COSMIC	YKENE	DEG_APCC_KENBOX_2	0.1667
p.H220Y	ACH-000849	Breast Cancer	CCLE	YKENE	DEG_APCC_KENBOX_2	0.1389
p.H220Y	MDA-MB-468	breast	COSMIC	YKENE	DEG_APCC_KENBOX_2	0.1389
p.T227S	ACH-000963	Colon/Colorectal Cancer	CCLE	YKENE	DEG_APCC_KENBOX_2	0.7116
p.T227S	CCK-81	large_intestine	COSMIC	YKENE	DEG_APCC_KENBOX_2	0.7116
p.P236S	ACH-000990	Endometrial/Uterine Cancer	CCLE	YKENE	DEG_APCC_KENBOX_2	0.3056
p.R221I	ACH-001559	Lung Cancer	CCLE	YKENE	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08603	Complement factor H	DEG_APCC_KENBOX_2	227:231	YKENE	APC,CDC20,FZR1	0.9093	More...
Q5H9L2	Transcription elongation factor A protein-like 5	DEG_APCC_KENBOX_2	5:9	YKENE	APC,CDC20,FZR1	0.8451	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: YKENE

Degron related mutations and impact score

Drug responses associated with CFH mutations

All proteins holding degron of YKENE