DegronMD

Uniprot ID: Q5H9L2

Source protein: Transcription elongation factor A protein-like 5

Source gene: TCEAL5

Class: DEG_APCC_KENBOX_2

Location: 5:9

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8451

ASA_SCORE: 121.86

COIL: 0.9102

CONS_SCORE: 0.5285

DSS_SCORE: 0.8434

HELIX: 0.066

FCONS_SCORE: 1.0492

RIG_SCORE: 0.6782

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R16I	TCGA-BS-A0UF	UCEC	TCGA	YKENE	DEG_APCC_KENBOX_2	0.1389
p.R16I	DO41488	UCEC	ICGC	YKENE	DEG_APCC_KENBOX_2	0.1389
p.E19D	TCGA-EO-A3AV	UCEC	TCGA	YKENE	DEG_APCC_KENBOX_2	0.0556
p.E19D	DO52412	UCEC	ICGC	YKENE	DEG_APCC_KENBOX_2	0.0556
p.P12R	DO224563	LUSC	ICGC	YKENE	DEG_APCC_KENBOX_2	0.25
p.E19K	SIDM00217	Colorectal Carcinoma	GDSC	YKENE	DEG_APCC_KENBOX_2	0.0556
p.E19K	ACH-000999	Colon/Colorectal Cancer	CCLE	YKENE	DEG_APCC_KENBOX_2	0.0556
p.E19K	SNU-1040	large_intestine	COSMIC	YKENE	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08603	Complement factor H	DEG_APCC_KENBOX_2	227:231	YKENE	APC,CDC20,FZR1	0.9093	More...
Q5H9L2	Transcription elongation factor A protein-like 5	DEG_APCC_KENBOX_2	5:9	YKENE	APC,CDC20,FZR1	0.8451	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons