DegronMD - P08833(IGFBP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V184I	TCGA-19-0957	GBM	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation altering degron motif	0.5965
p.V184I	DO11028	GBM	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation altering degron motif	0.5965
p.V184I	DO36103	PBCA	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation altering degron motif	0.5965
p.E192G	TCGA-36-2533	OV	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation rewiring degron network	0.1111
p.E192G	DO32516	OV	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation rewiring degron network	0.1111
p.K171I	TCGA-A5-A0GP	UCEC	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation substituting flanking lysine	0.3056
p.K171I	DO41109	UCEC	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation substituting flanking lysine	0.3056
p.V166A	TCGA-AA-A010	COAD	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation rewiring degron network	0.0556
p.R177Q	TCGA-AA-A010	COAD	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation altering degron motif	0.7329
p.R177Q	TCGA-AJ-A3EL	UCEC	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation altering degron motif	0.7329
p.R177Q	TCGA-AP-A056	UCEC	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation altering degron motif	0.7329
p.R177Q	TCGA-B5-A11N	UCEC	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation altering degron motif	0.7329
p.R177Q	TCGA-EY-A1GI	UCEC	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation altering degron motif	0.7329
p.R177Q	DO37474	SKCM	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation altering degron motif	0.7329
p.R177Q	DO41542	UCEC	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation altering degron motif	0.7329
p.R177Q	DO41211	UCEC	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation altering degron motif	0.7329
p.R177Q	DO41458	UCEC	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation altering degron motif	0.7329
p.R177Q	DO43971	UCEC	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation altering degron motif	0.7329
p.R177Q	SIDM00193	Colorectal Carcinoma	GDSC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation altering degron motif	0.7329
p.R177Q	ACH-000991	Colon/Colorectal Cancer	CCLE	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation altering degron motif	0.7329
p.R177Q	SNU-81	large intestine	COSMIC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation altering degron motif	0.7329
p.E174K	TCGA-AP-A5FX	UCEC	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation rewiring degron network	0.2778
p.E174K	DO49072	UCEC	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation rewiring degron network	0.2778
p.A188S	TCGA-BR-8286	STAD	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation rewiring degron network	0.2222
p.A188S	DO38400	STAD	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation rewiring degron network	0.2222
p.S186R	TCGA-CA-6717	COAD	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation rewiring degron network	0.2778
p.S186R	DO8264	COAD	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation rewiring degron network	0.2778
p.E185Q	TCGA-CV-A463	HNSC	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation rewiring degron network	0.3056
p.E185Q	DO52066	HNSC	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation rewiring degron network	0.3056
p.E185K	TCGA-DK-A6B5	BLCA	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation rewiring degron network	0.3056
p.E185K	DO48551	BLCA	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation rewiring degron network	0.3056
p.E192Q	TCGA-XF-AAMQ	BLCA	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation rewiring degron network	0.1111
p.E192Q	DO51934	BLCA	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation rewiring degron network	0.1111
p.G183E	DO222504	MELA	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation altering degron motif	0.7199
p.V188A	DO232761	PBCA	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation rewiring degron network	0.2222
p.V188I	DO230635	PRAD	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation rewiring degron network	0.2222
p.V188I	DO51407	PRAD	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation rewiring degron network	0.2222
p.G193R	DO229446	SKCA	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation rewiring degron network	0.0833
p.S177P	DO219773	UCEC	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation altering degron motif	0.6752
p.S177F	DO42665	UCEC	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation altering degron motif	0.7982
p.S194L	SIDM00291	Melanoma	GDSC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation blocking phosphorylation signal	0.5
p.S194L	ACH-002040	Skin Cancer	CCLE	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation blocking phosphorylation signal	0.5
p.S194L	HMV-II	skin	COSMIC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation blocking phosphorylation signal	0.5
p.V183I	SIDM00846	Cervical Carcinoma	GDSC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation altering degron motif	0.5965
p.V184L	SIDM00533	Pancreatic Carcinoma	GDSC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation altering degron motif	0.5654
p.V184L	ACH-000118	Pancreatic Cancer	CCLE	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation altering degron motif	0.5654
p.V184L	HuP-T3	pancreas	COSMIC	CRIELYRVV	DEG_APCC_DBOX_1	176:184	Mutation altering degron motif	0.5654

Kaplan plot for IGFBP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IGFBP1

UniProt ID: P08833

Entrez ID: 3484

Protein name: Insulin-like growth factor-binding protein 1 (IBP-1) (IGF-binding protein 1) (IGFBP-1) (Placental protein 12) (PP12)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IGFBP1 in