DegronMD

Uniprot ID: P08833

Source protein: Insulin-like growth factor-binding protein 1

Source gene: IGFBP1

Class: DEG_APCC_DBOX_1

Location: 176:184

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7455

ASA_SCORE: 71.8444

COIL: 0.3503

CONS_SCORE: 0.6378

DSS_SCORE: 0.1336

HELIX: 0.5923

FCONS_SCORE: 1.1797

RIG_SCORE: 0.9336

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V184I	TCGA-19-0957	GBM	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	0.5965
p.V184I	DO11028	GBM	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	0.5965
p.V184I	DO36103	PBCA	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	0.5965
p.E192G	TCGA-36-2533	OV	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	0.1111
p.E192G	DO32516	OV	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	0.1111
p.K171I	TCGA-A5-A0GP	UCEC	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	0.3056
p.K171I	DO41109	UCEC	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	0.3056
p.V166A	TCGA-AA-A010	COAD	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	0.0556
p.R177Q	TCGA-AA-A010	COAD	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	0.7329
p.R177Q	TCGA-AJ-A3EL	UCEC	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	0.7329
p.R177Q	TCGA-AP-A056	UCEC	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	0.7329
p.R177Q	TCGA-B5-A11N	UCEC	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	0.7329
p.R177Q	TCGA-EY-A1GI	UCEC	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	0.7329
p.R177Q	DO37474	SKCM	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	0.7329
p.R177Q	DO41542	UCEC	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	0.7329
p.R177Q	DO41211	UCEC	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	0.7329
p.R177Q	DO41458	UCEC	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	0.7329
p.R177Q	DO43971	UCEC	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	0.7329
p.R177Q	SIDM00193	Colorectal Carcinoma	GDSC	CRIELYRVV	DEG_APCC_DBOX_1	0.7329
p.R177Q	ACH-000991	Colon/Colorectal Cancer	CCLE	CRIELYRVV	DEG_APCC_DBOX_1	0.7329
p.R177Q	SNU-81	large_intestine	COSMIC	CRIELYRVV	DEG_APCC_DBOX_1	0.7329
p.E174K	TCGA-AP-A5FX	UCEC	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	0.2778
p.E174K	DO49072	UCEC	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	0.2778
p.A188S	TCGA-BR-8286	STAD	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	0.2222
p.A188S	DO38400	STAD	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	0.2222
p.S186R	TCGA-CA-6717	COAD	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	0.2778
p.S186R	DO8264	COAD	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	0.2778
p.E185Q	TCGA-CV-A463	HNSC	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	0.3056
p.E185Q	DO52066	HNSC	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	0.3056
p.E185K	TCGA-DK-A6B5	BLCA	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	0.3056
p.E185K	DO48551	BLCA	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	0.3056
p.E192Q	TCGA-XF-AAMQ	BLCA	TCGA	CRIELYRVV	DEG_APCC_DBOX_1	0.1111
p.E192Q	DO51934	BLCA	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	0.1111
p.G183E	DO222504	MELA	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	0.7199
p.V188A	DO232761	PBCA	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	0.2222
p.V188I	DO230635	PRAD	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	0.2222
p.V188I	DO51407	PRAD	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	0.2222
p.G193R	DO229446	SKCA	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	0.0833
p.S177P	DO219773	UCEC	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	0.6752
p.S177F	DO42665	UCEC	ICGC	CRIELYRVV	DEG_APCC_DBOX_1	0.7982
p.S194L	SIDM00291	Melanoma	GDSC	CRIELYRVV	DEG_APCC_DBOX_1	0.5
p.S194L	ACH-002040	Skin Cancer	CCLE	CRIELYRVV	DEG_APCC_DBOX_1	0.5
p.S194L	HMV-II	skin	COSMIC	CRIELYRVV	DEG_APCC_DBOX_1	0.5
p.V183I	SIDM00846	Cervical Carcinoma	GDSC	CRIELYRVV	DEG_APCC_DBOX_1	0.5965
p.V184L	SIDM00533	Pancreatic Carcinoma	GDSC	CRIELYRVV	DEG_APCC_DBOX_1	0.5654
p.V184L	ACH-000118	Pancreatic Cancer	CCLE	CRIELYRVV	DEG_APCC_DBOX_1	0.5654
p.V184L	HuP-T3	pancreas	COSMIC	CRIELYRVV	DEG_APCC_DBOX_1	0.5654

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: CRIELYRVV

Degron related mutations and impact score

Drug responses associated with IGFBP1 mutations

All proteins holding degron of CRIELYRVV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08833	Insulin-like growth factor-binding protein 1	DEG_APCC_DBOX_1	176:184	CRIELYRVV	APC,CDC20,FZR1	0.7455	More...