DegronMD - P08922(ROS1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M2275L	TCGA-17-Z031	LUAD	TCGA	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation altering degron motif	0.5999
p.R2269L	TCGA-60-2708	LUSC	TCGA	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation altering degron motif	0.8428
p.R2269L	DO26431	LUSC	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation altering degron motif	0.8428
p.G2284D	TCGA-AA-A010	COAD	TCGA	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.1111
p.G2284D	DO223130	ESCA	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.1111
p.T2266R	TCGA-AR-A0TP	BRCA	TCGA	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.2778
p.T2266R	DO1340	BRCA	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.2778
p.T2266M	TCGA-AX-A2IO	UCEC	TCGA	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.2778
p.T2266M	DO40800	UCEC	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.2778
p.P2260S	TCGA-B5-A11E	UCEC	TCGA	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.1111
p.P2260S	DO46394	OV	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.1111
p.P2260S	DO41644	UCEC	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.1111
p.E2265K	TCGA-D1-A16X	UCEC	TCGA	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.25
p.E2265K	TCGA-D3-A8GR	SKCM	TCGA	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.25
p.E2265K	TCGA-WE-AAA3	SKCM	TCGA	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.25
p.E2265K	DO51247	SKCM	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.25
p.E2265K	DO51295	SKCM	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.25
p.E2265K	DO41799	UCEC	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.25
p.M2264I	TCGA-D3-A8GM	SKCM	TCGA	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.2222
p.M2264I	TCGA-EE-A2MD	SKCM	TCGA	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.2222
p.M2264I	DO229177	LMS	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.2222
p.M2264I	DO222434	MELA	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.2222
p.M2264I	DO37851	SKCM	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.2222
p.M2264I	DO50288	SKCM	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.2222
p.N2268T	TCGA-FR-A3YN	SKCM	TCGA	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation altering degron motif	0.5944
p.N2268T	DO38111	SKCM	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation altering degron motif	0.5944
p.G2271R	TCGA-QB-A6FS	SKCM	TCGA	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation altering degron motif	0.6457
p.G2271R	DO222653	MELA	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation altering degron motif	0.6457
p.G2271R	DO48654	SKCM	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation altering degron motif	0.6457
p.T2279K	DO228948	LICA	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.25
p.R2269Q	DO228613	MALY	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation altering degron motif	0.7329
p.G2284S	DO222843	MELA	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.1111
p.L2277R	SIDM01954	Colorectal Carcinoma	GDSC	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.3056
p.Q2283K	SIDM01151	Hepatocellular Carcinoma	GDSC	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.1389
p.Q2283K	ACH-000483	Liver Cancer	CCLE	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.1389
p.Q2283K	SNU-182	liver	COSMIC	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.1389
p.T2279I	ACH-001367	Neuroblastoma	CCLE	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.25
p.Q2277K	SNU-182	liver	COSMIC	NREGLNYMV	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.3056

Kaplan plot for ROS1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ROS1

UniProt ID: P08922

Entrez ID: 6098

Protein name: Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ROS1 in