DegronMD

Uniprot ID: P08922

Source protein: Proto-oncogene tyrosine-protein kinase ROS

Source gene: ROS1

Class: DEG_APCC_DBOX_1

Location: 2268:2276

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5026

ASA_SCORE: 83.9

COIL: 0.6463

CONS_SCORE: 0.3096

DSS_SCORE: 0.3253

HELIX: 0.1613

FCONS_SCORE: 1.1214

RIG_SCORE: 0.8057

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M2275L	TCGA-17-Z031	LUAD	TCGA	NREGLNYMV	DEG_APCC_DBOX_1	0.5999
p.R2269L	TCGA-60-2708	LUSC	TCGA	NREGLNYMV	DEG_APCC_DBOX_1	0.8428
p.R2269L	DO26431	LUSC	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	0.8428
p.G2284D	TCGA-AA-A010	COAD	TCGA	NREGLNYMV	DEG_APCC_DBOX_1	0.1111
p.G2284D	DO223130	ESCA	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	0.1111
p.T2266R	TCGA-AR-A0TP	BRCA	TCGA	NREGLNYMV	DEG_APCC_DBOX_1	0.2778
p.T2266R	DO1340	BRCA	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	0.2778
p.T2266M	TCGA-AX-A2IO	UCEC	TCGA	NREGLNYMV	DEG_APCC_DBOX_1	0.2778
p.T2266M	DO40800	UCEC	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	0.2778
p.P2260S	TCGA-B5-A11E	UCEC	TCGA	NREGLNYMV	DEG_APCC_DBOX_1	0.1111
p.P2260S	DO46394	OV	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	0.1111
p.P2260S	DO41644	UCEC	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	0.1111
p.E2265K	TCGA-D1-A16X	UCEC	TCGA	NREGLNYMV	DEG_APCC_DBOX_1	0.25
p.E2265K	TCGA-D3-A8GR	SKCM	TCGA	NREGLNYMV	DEG_APCC_DBOX_1	0.25
p.E2265K	TCGA-WE-AAA3	SKCM	TCGA	NREGLNYMV	DEG_APCC_DBOX_1	0.25
p.E2265K	DO51247	SKCM	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	0.25
p.E2265K	DO51295	SKCM	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	0.25
p.E2265K	DO41799	UCEC	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	0.25
p.M2264I	TCGA-D3-A8GM	SKCM	TCGA	NREGLNYMV	DEG_APCC_DBOX_1	0.2222
p.M2264I	TCGA-EE-A2MD	SKCM	TCGA	NREGLNYMV	DEG_APCC_DBOX_1	0.2222
p.M2264I	DO229177	LMS	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	0.2222
p.M2264I	DO222434	MELA	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	0.2222
p.M2264I	DO37851	SKCM	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	0.2222
p.M2264I	DO50288	SKCM	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	0.2222
p.N2268T	TCGA-FR-A3YN	SKCM	TCGA	NREGLNYMV	DEG_APCC_DBOX_1	0.5944
p.N2268T	DO38111	SKCM	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	0.5944
p.G2271R	TCGA-QB-A6FS	SKCM	TCGA	NREGLNYMV	DEG_APCC_DBOX_1	0.6457
p.G2271R	DO222653	MELA	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	0.6457
p.G2271R	DO48654	SKCM	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	0.6457
p.T2279K	DO228948	LICA	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	0.25
p.R2269Q	DO228613	MALY	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	0.7329
p.G2284S	DO222843	MELA	ICGC	NREGLNYMV	DEG_APCC_DBOX_1	0.1111
p.L2277R	SIDM01954	Colorectal Carcinoma	GDSC	NREGLNYMV	DEG_APCC_DBOX_1	0.3056
p.Q2283K	SIDM01151	Hepatocellular Carcinoma	GDSC	NREGLNYMV	DEG_APCC_DBOX_1	0.1389
p.Q2283K	ACH-000483	Liver Cancer	CCLE	NREGLNYMV	DEG_APCC_DBOX_1	0.1389
p.Q2283K	SNU-182	liver	COSMIC	NREGLNYMV	DEG_APCC_DBOX_1	0.1389
p.T2279I	ACH-001367	Neuroblastoma	CCLE	NREGLNYMV	DEG_APCC_DBOX_1	0.25
p.Q2277K	SNU-182	liver	COSMIC	NREGLNYMV	DEG_APCC_DBOX_1	0.3056

Drug responses associated with ROS1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00720	MESO\|mesothelioma	p.R1506G (No)	GDSC	Crizotinib	57.174
SIDM00720	MESO\|mesothelioma	p.K1026M (No)	GDSC	Crizotinib	57.174
SIDM00720	MESO\|mesothelioma	p.F942L (No)	GDSC	Crizotinib	57.174
SIDM00223	SCLC\|lung_small_cell_carcinoma	p.N1087D (No)	GDSC	Crizotinib	33.2463
SIDM00515	SKCM\|melanoma	p.P1440S (No)	GDSC	Crizotinib	12.9798
SIDM00961	UNCLASSIFIED\|ewings_sarcoma	p.D2213E (No)	GDSC	Crizotinib	6.7664
SIDM00951	LAML\|acute_myeloid_leukaemia	p.D2113G (No)	GDSC	Crizotinib	0.492
SIDM00951	LAML\|acute_myeloid_leukaemia	p.D2113G (No)	GDSC	Crizotinib	0.2958
SIDM00951	LAML\|acute_myeloid_leukaemia	p.N1105S (No)	GDSC	Crizotinib	0.492
SIDM00951	LAML\|acute_myeloid_leukaemia	p.N1105S (No)	GDSC	Crizotinib	0.2958
SIDM00358	STAD\|stomach	p.Y1353S (No)	GDSC	Crizotinib	64.644
SIDM00614	LIHC\|liver	p.Y1353S (No)	GDSC	Crizotinib	50.621
SIDM00614	LIHC\|liver	p.W133R (No)	GDSC	Crizotinib	50.621
SIDM00271	UNCLASSIFIED\|stomach	p.E1902K (No)	GDSC	Crizotinib	31.188
SIDM00552	UNCLASSIFIED\|rhabdomyosarcoma	p.D209fs*22 (No)	GDSC	Crizotinib	6.9371
SIDM00552	UNCLASSIFIED\|rhabdomyosarcoma	p.D209fs*22 (No)	GDSC	Crizotinib	10.01
SIDM00145	ALL\|lymphoblastic_leukemia	p.L814I (No)	GDSC	Crizotinib	2.2997
SIDM00145	ALL\|lymphoblastic_leukemia	p.L814I (No)	GDSC	Crizotinib	13.523
SIDM00683	PRAD\|prostate	p.K991N (No)	GDSC	Crizotinib	22.2565
SIDM00683	PRAD\|prostate	p.K991N (No)	GDSC	Crizotinib	10.13
SIDM00079	OV\|ovary	p.L139V (No)	GDSC	Crizotinib	269.31
SIDM00901	UCEC\|endometrium	p.P675Q (No)	GDSC	Crizotinib	20.782
SIDM00849	KIRC\|kidney	p.N790S (No)	GDSC	Crizotinib	17.4345
SIDM00849	KIRC\|kidney	p.N790S (No)	GDSC	Crizotinib	6.1801
SIDM00524	SCLC\|lung_small_cell_carcinoma	p.P2182R (No)	GDSC	Crizotinib	28.3914
SIDM00524	SCLC\|lung_small_cell_carcinoma	p.P2182R (No)	GDSC	Crizotinib	26.956
SIDM00937	HNSC\|head_and_neck	p.D2102N (No)	GDSC	Crizotinib	10.732
SIDM00785	LAML\|acute_myeloid_leukaemia	p.R1506G (No)	GDSC	Crizotinib	19.4895
SIDM00785	LAML\|acute_myeloid_leukaemia	p.R1506G (No)	GDSC	Crizotinib	8.0563
SIDM00617	LIHC\|liver	p.N1726S (No)	GDSC	Crizotinib	95.568
SIDM00527	COREAD\|large_intestine	p.S653F (No)	GDSC	Crizotinib	24.5822
SIDM00527	COREAD\|large_intestine	p.S653F (No)	GDSC	Crizotinib	3.8606
SIDM01007	ALL\|lymphoblastic_leukemia	p.F106L (No)	GDSC	Crizotinib	2.6015
SIDM01007	ALL\|lymphoblastic_leukemia	p.F106L (No)	GDSC	Crizotinib	0.8455
SIDM01174	CESC\|cervix	p.R2072Q (No)	GDSC	Crizotinib	464.21
SIDM00142	UCEC\|endometrium	p.C532Y (No)	GDSC	Crizotinib	21.4851
SIDM00142	UCEC\|endometrium	p.C532Y (No)	GDSC	Crizotinib	17.515
SIDM00341	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.T2195S (No)	GDSC	Crizotinib	72.999
SIDM00980	STAD\|stomach	p.S1303N (No)	GDSC	Crizotinib	50.52
SIDM01056	BRCA\|breast	p.S551F (No)	GDSC	Crizotinib	30.59
SIDM00936	BLCA\|bladder	p.R1506G (No)	GDSC	Crizotinib	6.3451
SIDM00936	BLCA\|bladder	p.R560H (No)	GDSC	Crizotinib	6.3451
SIDM00251	STAD\|stomach	p.V1223F (No)	GDSC	Crizotinib	22.534
SIDM00971	BRCA\|breast	p.K2099N (No)	GDSC	Crizotinib	201.61
SIDM00971	BRCA\|breast	p.Q1091E (No)	GDSC	Crizotinib	201.61
SIDM00704	SCLC\|lung_small_cell_carcinoma	p.R201M (No)	GDSC	Crizotinib	11.0531
SIDM00704	SCLC\|lung_small_cell_carcinoma	p.R201M (No)	GDSC	Crizotinib	6.2491
SIDM01106	SKCM\|melanoma	p.S370P (No)	GDSC	Crizotinib	14.368
SIDM00586	LIHC\|liver	p.R2039H (No)	GDSC	Crizotinib	43.591
SIDM00498	COREAD\|large_intestine	p.S1345P (No)	GDSC	Crizotinib	6.9241
SIDM00551	ESCA\|oesophagus	p.G893R (No)	GDSC	Crizotinib	5.7698
SIDM00233	ALL\|lymphoblastic_T_cell_leukaemia	p.K1991R (No)	GDSC	Crizotinib	1.9933
SIDM00233	ALL\|lymphoblastic_T_cell_leukaemia	p.K1991R (No)	GDSC	Crizotinib	1.749
SIDM01129	SCLC\|lung_small_cell_carcinoma	p.R2039H (No)	GDSC	Crizotinib	6.8779
SIDM01129	SCLC\|lung_small_cell_carcinoma	p.R2039H (No)	GDSC	Crizotinib	7.0969
SIDM01197	COREAD\|large_intestine	p.P224S (No)	GDSC	Crizotinib	36.3426
SIDM01197	COREAD\|large_intestine	p.P224S (No)	GDSC	Crizotinib	3.774
SIDM01197	COREAD\|large_intestine	p.N13S (No)	GDSC	Crizotinib	36.3426
SIDM01197	COREAD\|large_intestine	p.N13S (No)	GDSC	Crizotinib	3.774
SIDM00482	LCML\|chronic_myeloid_leukaemia	p.G2245S (No)	GDSC	Crizotinib	8.4805
SIDM00482	LCML\|chronic_myeloid_leukaemia	p.G2245S (No)	GDSC	Crizotinib	1.4286
SIDM01039	UNCLASSIFIED\|urogenital_system_other	p.D2213E (No)	GDSC	Crizotinib	20.8078
SIDM01039	UNCLASSIFIED\|urogenital_system_other	p.Y1353S (No)	GDSC	Crizotinib	20.8078
SIDM00553	LAML\|leukemia	p.P224S (No)	GDSC	Crizotinib	12.1321
SIDM00553	LAML\|leukemia	p.P224S (No)	GDSC	Crizotinib	1.4683
SIDM00373	UCEC\|endometrium	p.L1167fs*1 (No)	GDSC	Crizotinib	22.273
SIDM00618	LIHC\|liver	p.G2293D (No)	GDSC	Crizotinib	66.771
SIDM00431	ALL\|lymphoblastic_T_cell_leukaemia	p.N790S (No)	GDSC	Crizotinib	3.3561
SIDM01117	SCLC\|lung_small_cell_carcinoma	p.E1902K (No)	GDSC	Crizotinib	7.8992
SIDM01117	SCLC\|lung_small_cell_carcinoma	p.G1824* (No)	GDSC	Crizotinib	7.8992
SIDM01117	SCLC\|lung_small_cell_carcinoma	p.S329F (No)	GDSC	Crizotinib	7.8992
SIDM01201	UNCLASSIFIED\|lymphoid_neoplasm_other	p.L2215P (No)	GDSC	Crizotinib	4.8212
SIDM00488	COREAD\|large_intestine	p.W133R (No)	GDSC	Crizotinib	7.8852
SIDM00411	PAAD\|pancreas	p.D725N (No)	GDSC	Crizotinib	186.77
SIDM00521	SCLC\|lung_small_cell_carcinoma	p.N1162K (No)	GDSC	Crizotinib	19.099
SIDM00791	LCML\|chronic_myeloid_leukaemia	p.R360I (No)	GDSC	Crizotinib	1.9828
SIDM00791	LCML\|chronic_myeloid_leukaemia	p.R360I (No)	GDSC	Crizotinib	14.212
SIDM00602	STAD\|stomach	p.D780G (No)	GDSC	Crizotinib	0.748
SIDM01045	UCEC\|endometrium	p.L1786I (No)	GDSC	Crizotinib	24.898
SIDM01028	ESCA\|oesophagus	p.L590P (No)	GDSC	Crizotinib	243.54
SIDM01121	SCLC\|lung_small_cell_carcinoma	p.S2299Y (No)	GDSC	Crizotinib	23.4821
SIDM01122	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A1443S (No)	GDSC	Crizotinib	38.353
SIDM00137	LUAD\|lung_NSCLC_adenocarcinoma	p.F1113S (No)	GDSC	Crizotinib	0.4166
SIDM01019	LAML\|acute_myeloid_leukaemia	p.R957S (No)	GDSC	Crizotinib	11.2173
SIDM01019	LAML\|acute_myeloid_leukaemia	p.R957S (No)	GDSC	Crizotinib	27.178
SIDM00495	DLBC\|B_cell_lymphoma	p.A642S (No)	GDSC	Crizotinib	4.7168
SIDM00495	DLBC\|B_cell_lymphoma	p.A642S (No)	GDSC	Crizotinib	1.5818
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.I369T (No)	GDSC	Crizotinib	77.815
SIDM00333	UCEC\|endometrium	p.V332I (No)	GDSC	Crizotinib	2.7499
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.E1902K (No)	GDSC	Crizotinib	6.4875
SIDM00530	ESCA\|oesophagus	p.D1853A (No)	GDSC	Crizotinib	11.688
SIDM00425	OV\|ovary	p.R2039H (No)	GDSC	Crizotinib	114.88
SIDM00489	HNSC\|head_and_neck	p.P224S (No)	GDSC	Crizotinib	37.564
SIDM01126	SCLC\|lung_small_cell_carcinoma	p.M792I (No)	GDSC	Crizotinib	11.7558
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.D1391V (No)	GDSC	Crizotinib	62.05
SIDM00256	NB\|neuroblastoma	p.L2000M (No)	GDSC	Crizotinib	3.0556
SIDM00256	NB\|neuroblastoma	p.L2000M (No)	GDSC	Crizotinib	12.374
SIDM00590	HNSC\|head_and_neck	p.P224S (No)	GDSC	Crizotinib	10.047
SIDM00428	LAML\|acute_myeloid_leukaemia	p.V530M (No)	GDSC	Crizotinib	4.39
SIDM00217	COREAD\|large_intestine	p.S1791N (No)	GDSC	Crizotinib	8.8254
SIDM00217	COREAD\|large_intestine	p.D780Y (No)	GDSC	Crizotinib	8.8254
SIDM00893	BRCA\|breast	p.D618E (No)	GDSC	Crizotinib	88.312
SIDM01199	LIHC\|liver	p.E1902K (No)	GDSC	Crizotinib	17.363
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.S1707N (No)	GDSC	Crizotinib	15.1838
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.S1707N (No)	GDSC	Crizotinib	18.219
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.D311N (No)	GDSC	Crizotinib	15.1838
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.D311N (No)	GDSC	Crizotinib	18.219
SIDM00280	UNCLASSIFIED\|stomach	p.E1902K (No)	GDSC	Crizotinib	17.838
SIDM00243	UNCLASSIFIED\|testis	p.W133R (No)	GDSC	Crizotinib	13.6724
SIDM00243	UNCLASSIFIED\|testis	p.W133R (No)	GDSC	Crizotinib	1.9015
SIDM00049	COREAD\|large_intestine	p.P217T (No)	GDSC	Crizotinib	32.44
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.G549S (No)	GDSC	Crizotinib	0.3965
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.P2130T (No)	GDSC	Crizotinib	19.9129
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.P2130T (No)	GDSC	Crizotinib	11.867
SIDM00477	ESCA\|oesophagus	p.F1295V (No)	GDSC	Crizotinib	1.8787
SIDM00282	COREAD\|large_intestine	p.T210A (No)	GDSC	Crizotinib	58.7424
SIDM00282	COREAD\|large_intestine	p.T210A (No)	GDSC	Crizotinib	25.263
SIDM00613	LGG\|glioma	p.Y164H (No)	GDSC	Crizotinib	20.2404
SIDM00613	LGG\|glioma	p.Y164H (No)	GDSC	Crizotinib	18.26
SIDM00479	ESCA\|oesophagus	p.R1506G (No)	GDSC	Crizotinib	18.627
SIDM00685	GBM\|glioma	p.W847C (No)	GDSC	Crizotinib	39.298
SIDM00363	LAML\|acute_myeloid_leukaemia	p.E1902K (No)	GDSC	Crizotinib	14.3968
SIDM00676	BLCA\|bladder	p.A87T (No)	GDSC	Crizotinib	127.05
SIDM00760	SCLC\|lung_small_cell_carcinoma	p.G764R (No)	GDSC	Crizotinib	9.1831
SIDM00760	SCLC\|lung_small_cell_carcinoma	p.G764R (No)	GDSC	Crizotinib	13.651
SIDM00668	UNCLASSIFIED\|Hodgkin_lymphoma	p.F518fs*8 (No)	GDSC	Crizotinib	14.1718
SIDM00668	UNCLASSIFIED\|Hodgkin_lymphoma	p.F518fs*8 (No)	GDSC	Crizotinib	3.7285
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.E290* (No)	GDSC	Crizotinib	181.79
SIDM00783	COREAD\|large_intestine	p.P151S (No)	GDSC	Crizotinib	2.3355
SIDM00673	BRCA\|breast	p.E1902K (No)	GDSC	Crizotinib	13.647
SIDM00557	NB\|neuroblastoma	p.D1776H (No)	GDSC	Crizotinib	1.3516
SIDM00996	THCA\|thyroid	p.P224S (No)	GDSC	Crizotinib	103.15
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.R1506G (No)	GDSC	Crizotinib	6.051
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.R1506G (No)	GDSC	Crizotinib	7.9484
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.N790S (No)	GDSC	Crizotinib	6.051
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.N790S (No)	GDSC	Crizotinib	7.9484
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.M792I (No)	GDSC	Crizotinib	16.4313
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.M792I (No)	GDSC	Crizotinib	32.08
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.D2189N (No)	GDSC	Crizotinib	80.6222
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.D2189N (No)	GDSC	Crizotinib	274.07
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P1941S (No)	GDSC	Crizotinib	80.6222
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P1941S (No)	GDSC	Crizotinib	274.07
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P208L (No)	GDSC	Crizotinib	80.6222
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P208L (No)	GDSC	Crizotinib	274.07
SIDM00867	GBM\|glioma	p.R2126L (No)	GDSC	Crizotinib	560.16
SIDM00867	GBM\|glioma	p.S653F (No)	GDSC	Crizotinib	560.16
SIDM00963	BRCA\|breast	p.V1916L (No)	GDSC	Crizotinib	38.7764
SIDM00963	BRCA\|breast	p.V1916L (No)	GDSC	Crizotinib	128.89
SIDM01008	DLBC\|B_cell_lymphoma	p.S370P (No)	GDSC	Crizotinib	17.7127
SIDM01008	DLBC\|B_cell_lymphoma	p.S370P (No)	GDSC	Crizotinib	5.292
SIDM00245	SCLC\|lung_small_cell_carcinoma	p.P224S (No)	GDSC	Crizotinib	10.0853
SIDM00245	SCLC\|lung_small_cell_carcinoma	p.P224S (No)	GDSC	Crizotinib	21.337
SIDM00585	LIHC\|liver	p.S1109A (No)	GDSC	Crizotinib	140.62
SIDM01033	BLCA\|bladder	p.P224S (No)	GDSC	Crizotinib	14.421
SIDM00582	PAAD\|pancreas	p.D1776H (No)	GDSC	Crizotinib	49.467
SIDM00265	UNCLASSIFIED\|ewings_sarcoma	p.G365A (No)	GDSC	Crizotinib	20.5133
SIDM00114	MESO\|mesothelioma	p.T2207S (No)	GDSC	Crizotinib	199.25
SIDM00541	COREAD\|large_intestine	p.P675Q (No)	GDSC	Crizotinib	3.1241
SIDM00616	LIHC\|liver	p.E1902K (No)	GDSC	Crizotinib	75.42
SIDM00328	ESCA\|oesophagus	p.E1902K (No)	GDSC	Crizotinib	45.3251
SIDM00328	ESCA\|oesophagus	p.E1902K (No)	GDSC	Crizotinib	83.234
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.A347V (No)	GDSC	Crizotinib	15.5121
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.A347V (No)	GDSC	Crizotinib	11.279
SIDM00548	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.P224S (No)	GDSC	Crizotinib	15.045
SIDM01233	COREAD\|large_intestine	p.Q1437K (No)	GDSC	Crizotinib	29.0616
SIDM01233	COREAD\|large_intestine	p.Q1437K (No)	GDSC	Crizotinib	68.42
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.T1290I (No)	GDSC	Crizotinib	46.0823
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.T1290I (No)	GDSC	Crizotinib	56.547
SIDM00895	DLBC\|B_cell_lymphoma	p.Q576* (No)	GDSC	Crizotinib	11.0773
SIDM01151	LIHC\|liver	p.Q2283K (Yes)	GDSC	Crizotinib	120.63
SIDM00119	LUAD\|lung_NSCLC_adenocarcinoma	p.G421W (No)	GDSC	Crizotinib	91.8978
SIDM00119	LUAD\|lung_NSCLC_adenocarcinoma	p.G421W (No)	GDSC	Crizotinib	107.9
SIDM00865	SCLC\|lung_small_cell_carcinoma	p.T870N (No)	GDSC	Crizotinib	41.7008
SIDM00865	SCLC\|lung_small_cell_carcinoma	p.T870N (No)	GDSC	Crizotinib	46.426
SIDM00803	KIRC\|kidney	p.S653F (No)	GDSC	Crizotinib	59.272
SIDM00547	UNCLASSIFIED\|lung_NSCLC_large_cell	p.T147A (No)	GDSC	Crizotinib	48.4927
SIDM00547	UNCLASSIFIED\|lung_NSCLC_large_cell	p.T147A (No)	GDSC	Crizotinib	1.1824
SIDM00890	SKCM\|melanoma	p.G631R (No)	GDSC	Crizotinib	45.895
SIDM01060	SKCM\|melanoma	p.E2296K (No)	GDSC	Crizotinib	42.628
SIDM00490	GBM\|glioma	p.V726I (No)	GDSC	Crizotinib	2.3909
SIDM00490	GBM\|glioma	p.V726I (No)	GDSC	Crizotinib	15.7
SIDM00834	COREAD\|large_intestine	p.R1286H (No)	GDSC	Crizotinib	18.399
SIDM00834	COREAD\|large_intestine	p.S370P (No)	GDSC	Crizotinib	18.399
SIDM01005	LAML\|acute_myeloid_leukaemia	p.E1902K (No)	GDSC	Crizotinib	20.7897
SIDM01005	LAML\|acute_myeloid_leukaemia	p.E1902K (No)	GDSC	Crizotinib	15.094
SIDM00230	SCLC\|lung_small_cell_carcinoma	p.S1306G (No)	GDSC	Crizotinib	25.1431
SIDM00230	SCLC\|lung_small_cell_carcinoma	p.S1306G (No)	GDSC	Crizotinib	5.8981
SIDM01259	ALL\|lymphoblastic_leukemia	p.D1966G (No)	GDSC	Crizotinib	7.4123
SIDM01259	ALL\|lymphoblastic_leukemia	p.D1966G (No)	GDSC	Crizotinib	23.738
SIDM01178	UNCLASSIFIED\|urogenital_system_other	p.G816W (No)	GDSC	Crizotinib	7.9609
SIDM00694	UNCLASSIFIED\|digestive_system_other	p.E1902K (No)	GDSC	Crizotinib	3.0984
SIDM00694	UNCLASSIFIED\|digestive_system_other	p.E1902K (No)	GDSC	Crizotinib	4.4852
SIDM00107	SKCM\|melanoma	p.P1020S (No)	GDSC	Crizotinib	34.117
SIDM00562	BRCA\|breast	p.Q1610* (No)	GDSC	Crizotinib	11.3575
SIDM00562	BRCA\|breast	p.Q1610* (No)	GDSC	Crizotinib	18.617
SIDM00562	BRCA\|breast	p.S661L (No)	GDSC	Crizotinib	11.3575
SIDM00562	BRCA\|breast	p.S661L (No)	GDSC	Crizotinib	18.617
SIDM00556	NB\|neuroblastoma	p.W133R (No)	GDSC	Crizotinib	39.0926
SIDM00556	NB\|neuroblastoma	p.W133R (No)	GDSC	Crizotinib	62.962
SIDM00878	BRCA\|breast	p.R1506G (No)	GDSC	Crizotinib	5.0363
SIDM00878	BRCA\|breast	p.N1105D (No)	GDSC	Crizotinib	5.0363
SIDM00878	BRCA\|breast	p.N790S (No)	GDSC	Crizotinib	5.0363
SIDM00410	ALL\|lymphoid_neoplasm_other	p.G1137* (No)	GDSC	Crizotinib	16.7172
SIDM00043	HNSC\|head_and_neck	p.P194S (No)	GDSC	Crizotinib	21.129
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.T927fs*7 (No)	GDSC	Crizotinib	9.5257
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.T927fs*7 (No)	GDSC	Crizotinib	3.0597
SIDM00193	COREAD\|large_intestine	p.E1737* (No)	GDSC	Crizotinib	42.439
SIDM00193	COREAD\|large_intestine	p.R1311Q (No)	GDSC	Crizotinib	42.439
SIDM00193	COREAD\|large_intestine	p.D725N (No)	GDSC	Crizotinib	42.439
SIDM00193	COREAD\|large_intestine	p.R380I (No)	GDSC	Crizotinib	42.439
SIDM00118	COREAD\|large_intestine	p.R2184I (No)	GDSC	Crizotinib	4.5563
SIDM00118	COREAD\|large_intestine	p.K1820R (No)	GDSC	Crizotinib	4.5563
SIDM00860	HNSC\|head_and_neck	p.Y2114C (No)	GDSC	Crizotinib	47.595

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NREGLNYMV

Degron related mutations and impact score

Drug responses associated with ROS1 mutations

All proteins holding degron of NREGLNYMV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08922	Proto-oncogene tyrosine-protein kinase ROS	DEG_APCC_DBOX_1	2268:2276	NREGLNYMV	APC,CDC20,FZR1	0.5026	More...