DegronMD - P09234(SNRPC)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S26I	TCGA-78-7536	LUAD	TCGA	HKENV	DEG_APCC_KENBOX_2	30:34	Mutation rewiring degron network	0.2222
p.Y38C	TCGA-AP-A059	UCEC	TCGA	HKENV	DEG_APCC_KENBOX_2	30:34	Mutation blocking phosphorylation signal	0.6667
p.K22N	TCGA-HF-7132	STAD	TCGA	HKENV	DEG_APCC_KENBOX_2	30:34	Mutation substituting flanking lysine	0.2222
p.K22N	SIDM00146	Breast Carcinoma	GDSC	HKENV	DEG_APCC_KENBOX_2	30:34	Mutation substituting flanking lysine	0.2222
p.K22N	ACH-000768	Breast Cancer	CCLE	HKENV	DEG_APCC_KENBOX_2	30:34	Mutation substituting flanking lysine	0.2222
p.K22N	MDA-MB-231	breast	COSMIC	HKENV	DEG_APCC_KENBOX_2	30:34	Mutation substituting flanking lysine	0.2222
p.V34L	TCGA-L9-A7SV	LUAD	TCGA	HKENV	DEG_APCC_KENBOX_2	30:34	Mutation altering degron motif	0.5654
p.R28W	TCGA-LN-A7HV	ESCA	TCGA	HKENV	DEG_APCC_KENBOX_2	30:34	Mutation rewiring degron network	0.2778
p.H24Q	TCGA-VS-A8QA	CESC	TCGA	HKENV	DEG_APCC_KENBOX_2	30:34	Mutation rewiring degron network	0.1667
p.L34V	DO233628	GACA	ICGC	HKENV	DEG_APCC_KENBOX_2	30:34	Mutation altering degron motif	0.6765
p.K43N	DO38214	STAD	ICGC	HKENV	DEG_APCC_KENBOX_2	30:34	Mutation rewiring degron network	0.0833
p.K43N	MDA-MB-231	breast	COSMIC	HKENV	DEG_APCC_KENBOX_2	30:34	Mutation rewiring degron network	0.0833
p.A32T	SNU-407	large intestine	COSMIC	HKENV	DEG_APCC_KENBOX_2	30:34	Mutation altering degron motif	0.7139

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons