DegronMD

Uniprot ID: P09234

Source protein: U1 small nuclear ribonucleoprotein C

Source gene: SNRPC

Class: DEG_APCC_KENBOX_2

Location: 30:34

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7353

ASA_SCORE: 54.98

COIL: 0.067

CONS_SCORE: 0.6878

DSS_SCORE: 0.2959

HELIX: 0.926

FCONS_SCORE: 1.0208

RIG_SCORE: 0.7497

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S26I	TCGA-78-7536	LUAD	TCGA	HKENV	DEG_APCC_KENBOX_2	0.2222
p.Y38C	TCGA-AP-A059	UCEC	TCGA	HKENV	DEG_APCC_KENBOX_2	0.6667
p.K22N	TCGA-HF-7132	STAD	TCGA	HKENV	DEG_APCC_KENBOX_2	0.2222
p.K22N	SIDM00146	Breast Carcinoma	GDSC	HKENV	DEG_APCC_KENBOX_2	0.2222
p.K22N	ACH-000768	Breast Cancer	CCLE	HKENV	DEG_APCC_KENBOX_2	0.2222
p.K22N	MDA-MB-231	breast	COSMIC	HKENV	DEG_APCC_KENBOX_2	0.2222
p.V34L	TCGA-L9-A7SV	LUAD	TCGA	HKENV	DEG_APCC_KENBOX_2	0.5654
p.R28W	TCGA-LN-A7HV	ESCA	TCGA	HKENV	DEG_APCC_KENBOX_2	0.2778
p.H24Q	TCGA-VS-A8QA	CESC	TCGA	HKENV	DEG_APCC_KENBOX_2	0.1667
p.L34V	DO233628	GACA	ICGC	HKENV	DEG_APCC_KENBOX_2	0.6765
p.K43N	DO38214	STAD	ICGC	HKENV	DEG_APCC_KENBOX_2	0.0833
p.K43N	MDA-MB-231	breast	COSMIC	HKENV	DEG_APCC_KENBOX_2	0.0833
p.A32T	SNU-407	large_intestine	COSMIC	HKENV	DEG_APCC_KENBOX_2	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P09234	U1 small nuclear ribonucleoprotein C	DEG_APCC_KENBOX_2	30:34	HKENV	APC,CDC20,FZR1	0.7353	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons