DegronMD - P09497(CLTB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R216C	TCGA-AD-6895	COAD	TCGA	LRSVLMSLK	DEG_APCC_DBOX_1	215:223	Mutation altering degron motif	0.8301
p.R216C	TCGA-AX-A0J0	UCEC	TCGA	LRSVLMSLK	DEG_APCC_DBOX_1	215:223	Mutation altering degron motif	0.8301
p.R216C	DO8938	COAD	ICGC	LRSVLMSLK	DEG_APCC_DBOX_1	215:223	Mutation altering degron motif	0.8301
p.R216C	DO228514	PRAD	ICGC	LRSVLMSLK	DEG_APCC_DBOX_1	215:223	Mutation altering degron motif	0.8301
p.R216C	DO41133	UCEC	ICGC	LRSVLMSLK	DEG_APCC_DBOX_1	215:223	Mutation altering degron motif	0.8301
p.K210E	TCGA-B5-A5OC	UCEC	TCGA	LRSVLMSLK	DEG_APCC_DBOX_1	215:223	Mutation substituting flanking lysine	0.3056
p.Q224L	TCGA-D7-A6EY	STAD	TCGA	LRSVLMSLK	DEG_APCC_DBOX_1	215:223	Mutation rewiring degron network	0.3056
p.L219P	TCGA-O8-A75V	LIHC	TCGA	LRSVLMSLK	DEG_APCC_DBOX_1	215:223	Mutation altering degron motif	0.7582
p.L219P	DO49716	LIHC	ICGC	LRSVLMSLK	DEG_APCC_DBOX_1	215:223	Mutation altering degron motif	0.7582
p.R211H	DO23546	LIRI	ICGC	LRSVLMSLK	DEG_APCC_DBOX_1	215:223	Mutation rewiring degron network	0.2222
p.Q206L	DO50118	STAD	ICGC	LRSVLMSLK	DEG_APCC_DBOX_1	215:223	Mutation rewiring degron network	0.0833
p.S205N	SIDM00014	Colorectal Carcinoma	GDSC	LRSVLMSLK	DEG_APCC_DBOX_1	215:223	Mutation blocking phosphorylation signal	0.5
p.S205N	LIM1215	large intestine	COSMIC	LRSVLMSLK	DEG_APCC_DBOX_1	215:223	Mutation blocking phosphorylation signal	0.5
p.Q224E	SIDM00143	Small Cell Lung Carcinoma	GDSC	LRSVLMSLK	DEG_APCC_DBOX_1	215:223	Mutation rewiring degron network	0.3056
p.Q224E	ACH-000803	Lung Cancer	CCLE	LRSVLMSLK	DEG_APCC_DBOX_1	215:223	Mutation rewiring degron network	0.3056
p.Q224E	COLO-668	lung	COSMIC	LRSVLMSLK	DEG_APCC_DBOX_1	215:223	Mutation rewiring degron network	0.3056
p.K210N	SIDM01770	Gastric Carcinoma	GDSC	LRSVLMSLK	DEG_APCC_DBOX_1	215:223	Mutation substituting flanking lysine	0.3056
p.K210N	ACH-000908	Gastric Cancer	CCLE	LRSVLMSLK	DEG_APCC_DBOX_1	215:223	Mutation substituting flanking lysine	0.3056
p.Q206E	COLO-668	lung	COSMIC	LRSVLMSLK	DEG_APCC_DBOX_1	215:223	Mutation rewiring degron network	0.0833

Kaplan plot for CLTB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLTB

UniProt ID: P09497

Entrez ID: 1212

Protein name: Clathrin light chain B (Lcb)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLTB in