DegronMD

Uniprot ID: P09497

Source protein: Clathrin light chain B

Source gene: CLTB

Class: DEG_APCC_DBOX_1

Location: 215:223

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9299

ASA_SCORE: 57.6667

COIL: 0.0976

CONS_SCORE: 0.9114

DSS_SCORE: 0.4278

HELIX: 0.9034

FCONS_SCORE: 1.0226

RIG_SCORE: 0.7855

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R216C	TCGA-AD-6895	COAD	TCGA	LRSVLMSLK	DEG_APCC_DBOX_1	0.8301
p.R216C	TCGA-AX-A0J0	UCEC	TCGA	LRSVLMSLK	DEG_APCC_DBOX_1	0.8301
p.R216C	DO8938	COAD	ICGC	LRSVLMSLK	DEG_APCC_DBOX_1	0.8301
p.R216C	DO228514	PRAD	ICGC	LRSVLMSLK	DEG_APCC_DBOX_1	0.8301
p.R216C	DO41133	UCEC	ICGC	LRSVLMSLK	DEG_APCC_DBOX_1	0.8301
p.K210E	TCGA-B5-A5OC	UCEC	TCGA	LRSVLMSLK	DEG_APCC_DBOX_1	0.3056
p.Q224L	TCGA-D7-A6EY	STAD	TCGA	LRSVLMSLK	DEG_APCC_DBOX_1	0.3056
p.L219P	TCGA-O8-A75V	LIHC	TCGA	LRSVLMSLK	DEG_APCC_DBOX_1	0.7582
p.L219P	DO49716	LIHC	ICGC	LRSVLMSLK	DEG_APCC_DBOX_1	0.7582
p.R211H	DO23546	LIRI	ICGC	LRSVLMSLK	DEG_APCC_DBOX_1	0.2222
p.Q206L	DO50118	STAD	ICGC	LRSVLMSLK	DEG_APCC_DBOX_1	0.0833
p.S205N	SIDM00014	Colorectal Carcinoma	GDSC	LRSVLMSLK	DEG_APCC_DBOX_1	0.5
p.S205N	LIM1215	large_intestine	COSMIC	LRSVLMSLK	DEG_APCC_DBOX_1	0.5
p.Q224E	SIDM00143	Small Cell Lung Carcinoma	GDSC	LRSVLMSLK	DEG_APCC_DBOX_1	0.3056
p.Q224E	ACH-000803	Lung Cancer	CCLE	LRSVLMSLK	DEG_APCC_DBOX_1	0.3056
p.Q224E	COLO-668	lung	COSMIC	LRSVLMSLK	DEG_APCC_DBOX_1	0.3056
p.K210N	SIDM01770	Gastric Carcinoma	GDSC	LRSVLMSLK	DEG_APCC_DBOX_1	0.3056
p.K210N	ACH-000908	Gastric Cancer	CCLE	LRSVLMSLK	DEG_APCC_DBOX_1	0.3056
p.Q206E	COLO-668	lung	COSMIC	LRSVLMSLK	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P09497	Clathrin light chain B	DEG_APCC_DBOX_1	215:223	LRSVLMSLK	APC,CDC20,FZR1	0.9299	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons