INHBB
UniProt ID: P09529
Entrez ID: 3625
Protein name: Inhibin beta B chain (Activin beta-B chain)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development a...
FUNCTION: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
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GO - Biological processes (BP):
activin receptor signaling pathway [GO:0032924]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; cellular response to cAMP [GO:0071320]; cellular response to cholesterol [GO:0071397]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleuk...
activin receptor signaling pathway [GO:0032924]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; cellular response to cAMP [GO:0071320]; cellular response to cholesterol [GO:0071397]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-1 [GO:0071347]; cellular response to leptin stimulus [GO:0044320]; cellular response to starvation [GO:0009267]; cellular response to Thyroglobulin triiodothyronine [GO:1904017]; cellular response to thyroid hormone stimulus [GO:0097067]; defense response [GO:0006952]; fat cell differentiation [GO:0045444]; negative regulation of follicle-stimulating hormone secretion [GO:0046882]; negative regulation of hepatocyte growth factor production [GO:0032686]; negative regulation of insulin secretion [GO:0046676]; oocyte development [GO:0048599]; ovarian follicle development [GO:0001541]; pituitary gland development [GO:0021983]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of follicle-stimulating hormone secretion [GO:0046881]; positive regulation of ovulation [GO:0060279]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; reproductive senescence [GO:1990636]; response to gonadotropin [GO:0034698]; response to insecticide [GO:0017085]; response to wounding [GO:0009611]; seminiferous tubule development [GO:0072520]; SMAD protein signal transduction [GO:0060395]; spermatogenesis [GO:0007283]
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GO - Molecular function (MF):
cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; host cell surface receptor binding [GO:0046789]; inhibin binding [GO:0034711]; protein-containing complex binding [GO:0044877]; protein homodimerization activity [GO:0042803]...
cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; host cell surface receptor binding [GO:0046789]; inhibin binding [GO:0034711]; protein-containing complex binding [GO:0044877]; protein homodimerization activity [GO:0042803]
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GO - Cellular component (CC):
cell periphery [GO:0071944]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; inhibin B complex [GO:0043513]; perinuclear region of cytoplasm [GO:0048471]...
cell periphery [GO:0071944]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; inhibin B complex [GO:0043513]; perinuclear region of cytoplasm [GO:0048471]
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INHBB
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Kaplan plot for INHBB in
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*NOTE: the Kaplan plots were collected from OncoLnc