DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
LQMRGR
Uniprot ID:
P09529
Source protein:
Inhibin beta B chain
Source gene:
INHBB
Class:
SCF_FBXL2
Location:
86:91
E3 ligase:
FBXL2
DEGRON score:
0.995
ASA_SCORE:
92.2833
COIL:
0.9648
CONS_SCORE:
0.5884
DSS_SCORE:
0.3954
HELIX:
0.024
FCONS_SCORE:
0.9221
RIG_SCORE:
0.7159
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.H81D
ACH-001568
Skin Cancer
CCLE
LQMRGR
SCF_FBXL2
0.1944
Drug responses associated with INHBB mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LQMRGR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P09529
Inhibin beta B chain
SCF_FBXL2
86:91
LQMRGR
FBXL2
0.995
More...