DegronMD - P09958(FURIN)

FUNCTION: Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:11799113, PubMed:1629222, PubMed:1713771, PubMed:2251280, PubMed:24666235, PubMed:25974265, PubMed:7592877, PubMed:7690548, PubMed:9130696). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (PubMed:7737999). Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-32) (PubMed:20489134, PubMed:21763278). By mediating processing of accessory subunit ATP6AP1/Ac45 of the V-ATPase, regulates the acidification of dense-core secretory granules in islets of Langerhans cells (By similarity). {ECO:0000250|UniProtKB:P23188, ECO:0000269|PubMed:11799113, ECO:0000269|PubMed:1629222, ECO:0000269|PubMed:1713771, ECO:0000269|PubMed:20489134, ECO:0000269|PubMed:21763278, ECO:0000269|PubMed:2251280, ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0000269|PubMed:7592877, ECO:0000269|PubMed:7690548, ECO:0000269|PubMed:7737999, ECO:0000269|PubMed:9130696}.; FUNCTION: (Microbial infection) Cleaves and activates diphtheria toxin DT. {ECO:0000269|PubMed:8253774}.; FUNCTION: (Microbial infection) Cleaves and activates anthrax toxin protective antigen (PA). {ECO:0000269|PubMed:1438214, ECO:0000269|PubMed:1644824}.; FUNCTION: (Microbial infection) Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin. {ECO:0000269|PubMed:25974265}.; FUNCTION: (Microbial infection) Able to cleave S.pneumoniae serine-rich repeat protein PsrP. {ECO:0000269|PubMed:27582320}.; FUNCTION: (Microbial infection) Facilitates human coronaviruses EMC and SARS-CoV-2 infections by proteolytically cleaving the spike protein at the monobasic S1/S2 cleavage site. This cleavage is essential for spike protein-mediated cell-cell fusion and entry into human lung cells. {ECO:0000269|PubMed:32362314}.; FUNCTION: (Microbial infection) Facilitates mumps virus infection by proteolytically cleaving the viral fusion protein F. {ECO:0000269|PubMed:32295904}. View more >>

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P119H	TCGA-AO-A128	BRCA	TCGA	KRDVYQE	LIG_APCC_ABBAyCdc20_2	106:112	Mutation rewiring degron network	0.1389
p.P119H	TCGA-AX-A06H	UCEC	TCGA	KRDVYQE	LIG_APCC_ABBAyCdc20_2	106:112	Mutation rewiring degron network	0.1389
p.P119H	DO5326	BRCA	ICGC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	106:112	Mutation rewiring degron network	0.1389
p.P119H	DO43530	UCEC	ICGC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	106:112	Mutation rewiring degron network	0.1389
p.R104Q	TCGA-CM-6161	COAD	TCGA	KRDVYQE	LIG_APCC_ABBAyCdc20_2	106:112	Mutation rewiring degron network	0.2778
p.R104Q	DO10116	COAD	ICGC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	106:112	Mutation rewiring degron network	0.2778
p.K117T	TCGA-EO-A3AV	UCEC	TCGA	KRDVYQE	LIG_APCC_ABBAyCdc20_2	106:112	Mutation substituting flanking lysine	0.3056
p.K117T	DO52412	UCEC	ICGC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	106:112	Mutation substituting flanking lysine	0.3056
p.E112Q	TCGA-VS-A8EK	CESC	TCGA	KRDVYQE	LIG_APCC_ABBAyCdc20_2	106:112	Mutation altering degron motif	0.6744
p.E112Q	DO51623	CESC	ICGC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	106:112	Mutation altering degron motif	0.6744
p.R107Q	DO224676	BRCA	ICGC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	106:112	Mutation altering degron motif	0.6218
p.Q121H	DO228976	LICA	ICGC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	106:112	Mutation rewiring degron network	0.0833
p.V109M	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	106:112	Mutation altering degron motif	0.6097
p.V109M	SIDM00844	Burkitt's Lymphoma	GDSC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	106:112	Mutation altering degron motif	0.6097
p.V109M	SIDM00930	Osteosarcoma	GDSC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	106:112	Mutation altering degron motif	0.6097
p.V109M	SIDM00720	Mesothelioma	GDSC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	106:112	Mutation altering degron motif	0.6097
p.R104W	SIDM00332	Breast Carcinoma	GDSC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	106:112	Mutation rewiring degron network	0.2778
p.R104W	ACH-001819	Breast Cancer	CCLE	KRDVYQE	LIG_APCC_ABBAyCdc20_2	106:112	Mutation rewiring degron network	0.2778
p.R104W	MFM-223	breast	COSMIC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	106:112	Mutation rewiring degron network	0.2778
p.Q121R	SIDM00121	T-Lymphoblastic Leukemia	GDSC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	106:112	Mutation rewiring degron network	0.0833
p.Q121R	ACH-001738	Leukemia	CCLE	KRDVYQE	LIG_APCC_ABBAyCdc20_2	106:112	Mutation rewiring degron network	0.0833
p.Q121R	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	106:112	Mutation rewiring degron network	0.0833

Kaplan plot for FURIN in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FURIN

UniProt ID: P09958

Entrez ID: 5045

Protein name: Furin (EC 3.4.21.75) (Dibasic-processing enzyme) (Paired basic amino acid residue-cleaving enzyme) (PACE)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for FURIN in