DegronMD

Uniprot ID: P09958

Source protein: Furin

Source gene: FURIN

Class: LIG_APCC_ABBAyCdc20_2

Location: 106:112

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8944

ASA_SCORE: 105.1714

COIL: 0.8079

CONS_SCORE: 0.3708

DSS_SCORE: 0.6098

HELIX: 0.0829

FCONS_SCORE: 0.7746

RIG_SCORE: 0.7441

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P119H	TCGA-AO-A128	BRCA	TCGA	KRDVYQE	LIG_APCC_ABBAyCdc20_2	0.1389
p.P119H	TCGA-AX-A06H	UCEC	TCGA	KRDVYQE	LIG_APCC_ABBAyCdc20_2	0.1389
p.P119H	DO5326	BRCA	ICGC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	0.1389
p.P119H	DO43530	UCEC	ICGC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R104Q	TCGA-CM-6161	COAD	TCGA	KRDVYQE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R104Q	DO10116	COAD	ICGC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	0.2778
p.K117T	TCGA-EO-A3AV	UCEC	TCGA	KRDVYQE	LIG_APCC_ABBAyCdc20_2	0.3056
p.K117T	DO52412	UCEC	ICGC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	0.3056
p.E112Q	TCGA-VS-A8EK	CESC	TCGA	KRDVYQE	LIG_APCC_ABBAyCdc20_2	0.6744
p.E112Q	DO51623	CESC	ICGC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	0.6744
p.R107Q	DO224676	BRCA	ICGC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	0.6218
p.Q121H	DO228976	LICA	ICGC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	0.0833
p.V109M	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	0.6097
p.V109M	SIDM00844	Burkitt's Lymphoma	GDSC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	0.6097
p.V109M	SIDM00930	Osteosarcoma	GDSC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	0.6097
p.V109M	SIDM00720	Mesothelioma	GDSC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	0.6097
p.R104W	SIDM00332	Breast Carcinoma	GDSC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R104W	ACH-001819	Breast Cancer	CCLE	KRDVYQE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R104W	MFM-223	breast	COSMIC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	0.2778
p.Q121R	SIDM00121	T-Lymphoblastic Leukemia	GDSC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	0.0833
p.Q121R	ACH-001738	Leukemia	CCLE	KRDVYQE	LIG_APCC_ABBAyCdc20_2	0.0833
p.Q121R	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	KRDVYQE	LIG_APCC_ABBAyCdc20_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P09958	Furin	LIG_APCC_ABBAyCdc20_2	106:112	KRDVYQE	APC,CDC20,FZR1	0.8944	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons